Methoxy-PEPy

Modify Date: 2025-08-20 18:22:23

Methoxy-PEPy structure	Common Name	Methoxy-PEPy
	CAS Number	524924-76-3	Molecular Weight	210.23100
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₃H₁₀N₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Methoxy-PEPy

Methoxy-PEPy is a potent and highly selective mGlu5 receptor antagonist with IC50 of 1 nM.IC50 value: 1 nM [1]Target: mGlu5R inhibitorAdministration of [3H]methoxy-PEPy (50 microCi/kg i.v.) to mGlu5 receptor-deficient mice revealed binding at background levels in forebrain, whereas wild-type mice exhibited 14-fold higher binding in forebrain relative to cerebellum [2]. The calcium transients stimulated by these agonists were potently inhibited by reference allosteric mGlu5 antagonists - 2-methyl-6-(phenylethynyl)pyridine (MPEP), 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) and 3-methoxy-5-(pyridine-2-ylethynyl)pyridine (methoxy-PEPy) (IC(50) ranges: 0.8-66 nM) [3].

Name	Methoxy-PEPy
Synonym	More Synonyms

Description	Methoxy-PEPy is a potent and highly selective mGlu5 receptor antagonist with IC50 of 1 nM.IC50 value: 1 nM [1]Target: mGlu5R inhibitorAdministration of [3H]methoxy-PEPy (50 microCi/kg i.v.) to mGlu5 receptor-deficient mice revealed binding at background levels in forebrain, whereas wild-type mice exhibited 14-fold higher binding in forebrain relative to cerebellum [2]. The calcium transients stimulated by these agonists were potently inhibited by reference allosteric mGlu5 antagonists - 2-methyl-6-(phenylethynyl)pyridine (MPEP), 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) and 3-methoxy-5-(pyridine-2-ylethynyl)pyridine (methoxy-PEPy) (IC(50) ranges: 0.8-66 nM) [3].
Related Catalog	Research Areas >> Neurological Disease
References	[1]. Cosford ND, et al. [3H]-methoxymethyl-MTEP and [3H]-methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor. Bioorg Med Chem Lett. 2003 Feb 10;13(3):351-4. [2]. Anderson JJ, et al. In vivo receptor occupancy of mGlu5 receptor antagonists using the novel radioligand [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine). Eur J Pharmacol. 2003 Jul 18;473(1):35-40. [3]. Salisbury BG, et al. Inducible expression and pharmacological characterization of the mouse metabotropic glutamate 5b receptor. Eur J Pharmacol. 2008 Jan 28;579(1-3):34-9.

Description

Related Catalog

Research Areas >> Neurological Disease

References

[1]. Cosford ND, et al. [3H]-methoxymethyl-MTEP and [3H]-methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor. Bioorg Med Chem Lett. 2003 Feb 10;13(3):351-4.

[2]. Anderson JJ, et al. In vivo receptor occupancy of mGlu5 receptor antagonists using the novel radioligand [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine). Eur J Pharmacol. 2003 Jul 18;473(1):35-40.

[3]. Salisbury BG, et al. Inducible expression and pharmacological characterization of the mouse metabotropic glutamate 5b receptor. Eur J Pharmacol. 2008 Jan 28;579(1-3):34-9.

Molecular Formula	C₁₃H₁₀N₂O
Molecular Weight	210.23100
Exact Mass	210.07900
PSA	35.01000
LogP	1.88500
InChIKey	VRTFKUFTEWQHDD-UHFFFAOYSA-N
SMILES	COc1cncc(C#Cc2ccccn2)c1
Storage condition	2-8℃

3-methoxy-5-(pyridin-2-ylethynyl)pyridine

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Methoxy-PEPy
Price: Check
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China
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: Methoxy-PEPy
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3-Methoxy-5-(pyridin-2-ylethynyl)pyridine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Price: $462/10mM*1mLinDMSO

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Methoxy-PEPy

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