甲氧基PEPy

• 常用名: 甲氧基PEPy
• 英文名: Methoxy-PEPy
• CAS号: 524924-76-3
• 分子量: 210.23100
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₃H₁₀N₂O
• 熔点: N/A
• 闪点: N/A

甲氧基PEPy用途

Methoxy-PEPy是mGlu5受体高效选择性抑制剂，IC50值为1nM。

甲氧基PEPy名称

• 中文名: 甲氧基PEPy
• 英文名: Methoxy-PEPy

甲氧基PEPy生物活性

• 描述: Methoxy-PEPy是mGlu5受体高效选择性抑制剂,IC50值为1nM。
• 相关类别:
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Cosford ND, et al. [3H]-methoxymethyl-MTEP and [3H]-methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor. Bioorg Med Chem Lett. 2003 Feb 10;13(3):351-4.

  [2]. Anderson JJ, et al. In vivo receptor occupancy of mGlu5 receptor antagonists using the novel radioligand [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine). Eur J Pharmacol. 2003 Jul 18;473(1):35-40.

  [3]. Salisbury BG, et al. Inducible expression and pharmacological characterization of the mouse metabotropic glutamate 5b receptor. Eur J Pharmacol. 2008 Jan 28;579(1-3):34-9.

甲氧基PEPy物理化学性质

• 分子式: C₁₃H₁₀N₂O
• 分子量: 210.23100
• 精确质量: 210.07900
• PSA: 35.01000
• LogP: 1.88500
• InChIKey: VRTFKUFTEWQHDD-UHFFFAOYSA-N
• SMILES: COc1cncc(C#Cc2ccccn2)c1
• 储存条件: 2-8℃

甲氧基PEPy靶点实验

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实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：qHTS for Inhibitors of AMA1-RON; Towards Development of Antimalarial Drug Lead: Prima... 来源：NCGC 靶标：apical membrane antigen 1, AMA1 [Plasmodium falciparum 3D7] External Id：AMA1100

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：abhydrolase domain-containing protein 4 isoform 1 [Mus musculus] External Id：ABHD4_INH_FP_1536_1X%INH PRUN

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甲氧基PEPy英文别名

• 3-methoxy-5-(pyridin-2-ylethynyl)pyridine