Tetramethylcurcumin
Tetramethylcurcumin structure
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Common Name | Tetramethylcurcumin | ||
|---|---|---|---|---|
| CAS Number | 52328-97-9 | Molecular Weight | 424.486 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 594.5±50.0 °C at 760 mmHg | |
| Molecular Formula | C25H28O6 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 255.1±30.2 °C | |
Use of TetramethylcurcuminTetramethylcurcumin (FLLL31), derived from curcumin, specifically suppresses the phosphorylation of STAT3 by binding selectively to Janus kinase 2 and the STAT3 Src homology-2 domain. Tetramethylcurcumin exhibits anti-inflammatory and anti-cancer effects[1][2]. |
| Name | (1E,6E)-1,7-bis(3,4-dimethoxyphenyl)-4,4-dimethylhepta-1,6-diene-3,5-dione |
|---|---|
| Synonym | More Synonyms |
| Description | Tetramethylcurcumin (FLLL31), derived from curcumin, specifically suppresses the phosphorylation of STAT3 by binding selectively to Janus kinase 2 and the STAT3 Src homology-2 domain. Tetramethylcurcumin exhibits anti-inflammatory and anti-cancer effects[1][2]. |
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| Related Catalog | |
| Target |
STAT3 |
| In Vitro | Tetramethylcurcumin (FLLL31; 2.5 and 5 µM; for 24 hours) downregulats STAT3 phosphorylation and DNA-binding activity in MDA-MB-231 breast and PANC-1 pancreatic cancer cells[1]. Tetramethylcurcumin inhibits cell viability, cell invasion. Tetramethylcurcumin is a effective inhibitor of STAT3 phosphorylation, DNA-binding activity, and transactivation in vitro, leading to the impediment of multiple oncogenic processes and the induction of apoptosis in pancreatic and breast cancer cell lines[1]. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 594.5±50.0 °C at 760 mmHg |
| Molecular Formula | C25H28O6 |
| Molecular Weight | 424.486 |
| Flash Point | 255.1±30.2 °C |
| Exact Mass | 424.188599 |
| PSA | 71.06000 |
| LogP | 4.81 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.575 |
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~78%
Tetramethylcurcumin CAS#:52328-97-9 |
| Literature: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION; LI, Pui-Kai; LI, Chenglong; LIN, Jiayuh; FUCHS, James, R. Patent: WO2010/121007 A1, 2010 ; Location in patent: Page/Page column 5; 14-15 ; |
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~%
Tetramethylcurcumin CAS#:52328-97-9 |
| Literature: Bayomi, Said M.; El-Kashef, Hassan A.; El-Ashmawy, Mahmoud B.; Nasr, Magda N. A.; El-Sherbeny, Magda A.; Badria, Farid A.; Abou-Zeid, Laila A.; Ghaly, Mariam A.; Abdel-Aziz, Naglaa I. Medicinal Chemistry Research, 2013 , vol. 22, # 3 p. 1147 - 1162 |
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~%
Tetramethylcurcumin CAS#:52328-97-9 |
| Literature: Bayomi, Said M.; El-Kashef, Hassan A.; El-Ashmawy, Mahmoud B.; Nasr, Magda N. A.; El-Sherbeny, Magda A.; Badria, Farid A.; Abou-Zeid, Laila A.; Ghaly, Mariam A.; Abdel-Aziz, Naglaa I. Medicinal Chemistry Research, 2013 , vol. 22, # 3 p. 1147 - 1162 |
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Interleukin-17 Stimulates STAT3-Mediated Endothelial Cell Activation for Neutrophil Recruitment.
Cell Physiol. Biochem. 36 , 2340-56, (2015) Interleukin-17 (IL-17) is a major pro-inflammatory cytokine that initiates and maintains inflammation. However, the molecular mechanisms as to how IL-17 influences endothelial cells to promote neutrop... |
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Modulation of cell metabolic pathways and oxidative stress signaling contribute to acquired melphalan resistance in multiple myeloma cells.
PLoS ONE 10(3) , e0119857, (2015) Alkylating agents are widely used chemotherapeutics in the treatment of many cancers, including leukemia, lymphoma, multiple myeloma, sarcoma, lung, breast and ovarian cancer. Melphalan is the most co... |
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Effect of LIF-withdrawal on acetylcholine synthesis in the embryonic stem cell line CGR8 is not mediated by STAT3, PI3Ks or cAMP/PKA pathways.
Int. Immunopharmacol. 29 , 115-8, (2015) Acetylcholine (ACh) acts as a local cellular signaling molecule and is widely expressed in nature, including mammalian cells and embryonic stem cells. The murine embryonic stem cell line CGR8 synthesi... |
| FLLL31 |
| (E,E)-1,7-Bis(3,4-dimethoxyphenyl)-4,4-dimethyl-1,6-heptadiene-3,5-dione |
| Tetramethylcurcumin |
| (1E,6E)-1,7-Bis(3,4-dimethoxyphenyl)-4,4-dimethyl-1,6-heptadiene-3,5-dione |
| 1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4,4-dimethyl-, (1E,6E)- |
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Tetramethylcurcumin
- Price: ￥1478.0/20mg
- Purity: 98.0%
- Stocking Period: 1 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: FLLL31
- Price: $600.0/100mg $1100.0/250mg $2200.0/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Zhejiang Hangyu API Co., Ltd
- China
- Product Name: FLLL31
- Price: ￥Inquiry/1kg
- Purity: 99.5%
- Stocking Period: Inquiry
- Contact: Vinnie
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