Antimycin A3

Modify Date: 2025-08-24 17:37:26

Antimycin A3 Structure
Antimycin A3 structure
Common Name Antimycin A3
CAS Number 522-70-3 Molecular Weight 520.57200
Density 1.25g/cm3 Boiling Point 745.5ºC at 760mmHg
Molecular Formula C26H36N2O9 Melting Point N/A
MSDS N/A Flash Point 404.7ºC

 Use of Antimycin A3


Antimycin A3, an antibiotic isolated from a number of Streptomyces species, shows antifungal activities. Antimycin A3 is a potent inhibitor of respiration. Antimycin A3 inhibits the electron transfer activity of ubiquinol-cytochrome c oxidoreductase. Antimycin A3 inhibits ATP-citrate lyase with a Ki value of 60.1 µM[1][2][3].

 Names

Name Butanoic acid, 2(or3)-methyl-,(2R,3S,6S,7R,8R)-3-[[3-(formylamino)-2-hydroxybenzoyl]amino]-8-butyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-ylester
Synonym More Synonyms

 Antimycin A3 Biological Activity

Description Antimycin A3, an antibiotic isolated from a number of Streptomyces species, shows antifungal activities. Antimycin A3 is a potent inhibitor of respiration. Antimycin A3 inhibits the electron transfer activity of ubiquinol-cytochrome c oxidoreductase. Antimycin A3 inhibits ATP-citrate lyase with a Ki value of 60.1 µM[1][2][3].
Related Catalog
In Vitro Antimycin A3 induces apoptosis of cancer cells by selectively killing cancer cells that expressed high levels of anti-apoptotic Bcl-2 and Bcl-XL[1].
References

[1]. Ade Arsianti, et al. Synthesis and anticancer activity of polyhydroxylated 18-membered analogue of antimycin A3. Tetrahedron.Volume 68, Issue 13, 1 April 2012, Pages 2884-2891.

[2]. Miyoshi H, et al. Inhibition of electron transport of rat liver mitochondria by unnatural (-)-antimycin A3.

[3]. Barrow CJ, et al. Antimycins, inhibitors of ATP-citrate lyase, from a Streptomyces sp. J Antibiot (Tokyo). 1997 Sep;50(9):729-33.

 Chemical & Physical Properties

Density 1.25g/cm3
Boiling Point 745.5ºC at 760mmHg
Molecular Formula C26H36N2O9
Molecular Weight 520.57200
Flash Point 404.7ºC
Exact Mass 520.24200
PSA 157.33000
LogP 3.80000
Index of Refraction 1.549
InChIKey PVEVXUMVNWSNIG-PDPGNHKXSA-N
SMILES CCCCC1C(=O)OC(C)C(NC(=O)c2cccc(NC=O)c2O)C(=O)OC(C)C1OC(=O)CC(C)C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NY1502900
CHEMICAL NAME :
Isovaleric acid, N-ester with N-(7-butyl-8-hydroxy-4,9-dimethyl-2,6-dioxo-1,5-dioxo nan-3-yl) -3-formamidosalicylamide, stereoisomer
CAS REGISTRY NUMBER :
522-70-3
LAST UPDATED :
199709
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C26-H36-N2-O9
MOLECULAR WEIGHT :
520.64
WISWESSER LINE NOTATION :
T9OV EOVTJ CMVR BQ CMVH& D1 G4 HOV1Y1&1 I1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 10,39,1957
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 10,39,1957
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
900 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,145,1967

 Safety Information

Risk Phrases 23/24/25
RIDADR UN 3172
WGK Germany 2
RTECS EB3140000
Packaging Group II
Hazard Class 6.1(a)

 Synonyms

antimycina3
ioxonan-3-yl)-3-formamidosalicylamide,stereoisomer
Blastmycin
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.
Top Suppliers:I want be here



Get all suppliers and price by the below link:

Antimycin A3 suppliers

Antimycin A3 price