TNP
TNP structure
|
Common Name | TNP | ||
|---|---|---|---|---|
| CAS Number | 519178-28-0 | Molecular Weight | 443.38200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H16F3N7O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of TNPIP3K Inhibitor is a IP3K inhibitor with an IC50 of 10.2 μM. |
| Name | 6-N-[(4-nitrophenyl)methyl]-2-N-[[3-(trifluoromethyl)phenyl]methyl]-7H-purine-2,6-diamine |
|---|---|
| Synonym | More Synonyms |
| Description | IP3K Inhibitor is a IP3K inhibitor with an IC50 of 10.2 μM. |
|---|---|
| Related Catalog | |
| Target |
IC50: 10.2 μM (IP3K)[1] |
| In Vitro | IP3K Inhibitor binds to the ATP binding site of IP3K with an inhibition constant Ki of 4.3 μM. IP3K Inhibitor is a significantly weaker inhibitor of CDK1 (IC50>100 μM). Upon treatment with IP3K Inhibitor, the intracellular calcium level increases over 1±2 mins in a dose-dependent manner and any subsequent ATP-induced calcium release was almost completely absent at a 20 μM concentration of IP3K Inhibitor[1]. |
| References |
| Molecular Formula | C20H16F3N7O2 |
|---|---|
| Molecular Weight | 443.38200 |
| Exact Mass | 443.13200 |
| PSA | 127.57000 |
| LogP | 4.52220 |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H300-H319 |
| Precautionary Statements | P264-P301 + P310-P305 + P351 + P338 |
| RIDADR | UN 2811 6.1 / PGIII |
|
Development of anti-HER2 fragment antibody conjugated to iron oxide nanoparticles for in vivo HER2-targeted photoacoustic tumor imaging.
Nanomedicine: Nanotechnology, Biology, and Medicine 11 , 2051-60, (2015) Photoacoustic (PA) imaging is a promising imaging modality that provides biomedical information with high sensitivity and resolution. Iron oxide nanoparticles (IONPs) have been regarded as remarkable ... |
|
|
Regulation of the Min Cell Division Inhibition Complex by the Rcs Phosphorelay in Proteus mirabilis.
J. Bacteriol. 197 , 2499-507, (2015) A key regulator of swarming in Proteus mirabilis is the Rcs phosphorelay, which represses flhDC, encoding the master flagellar regulator FlhD4C2. Mutants in rcsB, the response regulator in the Rcs pho... |
|
|
Facilitated monocyte-macrophage uptake and tissue distribution of superparmagnetic iron-oxide nanoparticles.
PLoS ONE 4 , e4343, (2009) We posit that the same mononuclear phagocytes (MP) that serve as target cells and vehicles for a host of microbial infections can be used to improve diagnostics and drug delivery. We also theorize tha... |
| N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-1H-Purine-2,6-diamine |
| N2-(m-Trifluorobenzyl) (N6-(p-nitrobenzyl)purine |
| Purine,5 |
| IP3K Inhibitor |
| N2-(m-Trifluorobenzyl),N6-(p-nitrobenzyl)purine |
| Inositol-1,4,5-trisphosphate 3-Kinase Inhibitor |