519178-28-0

519178-28-0 structure

Name: TNP
Chemical Name: 6-N-[(4-nitrophenyl)methyl]-2-N-[[3-(trifluoromethyl)phenyl]methyl]-7H-purine-2,6-diamine
CAS Number: 519178-28-0
Molecular Formula: C₂₀H₁₆F₃N₇O₂
Molecular Weight: 443.38200
Catalog: Research Areas Cancer
Create Date: 2018-06-22 11:39:33
Modify Date: 2024-01-02 09:47:01
IP3K Inhibitor is a IP3K inhibitor with an IC50 of 10.2 μM.

Name	6-N-[(4-nitrophenyl)methyl]-2-N-[[3-(trifluoromethyl)phenyl]methyl]-7H-purine-2,6-diamine
Synonyms	N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-1H-Purine-2,6-diamine N2-(m-Trifluorobenzyl) (N6-(p-nitrobenzyl)purine Purine,5 IP3K Inhibitor N2-(m-Trifluorobenzyl),N6-(p-nitrobenzyl)purine Inositol-1,4,5-trisphosphate 3-Kinase Inhibitor

Description	IP3K Inhibitor is a IP3K inhibitor with an IC50 of 10.2 μM.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer
Target	IC50: 10.2 μM (IP3K)[1]
In Vitro	IP3K Inhibitor binds to the ATP binding site of IP3K with an inhibition constant Ki of 4.3 μM. IP3K Inhibitor is a significantly weaker inhibitor of CDK1 (IC50>100 μM). Upon treatment with IP3K Inhibitor, the intracellular calcium level increases over 1±2 mins in a dose-dependent manner and any subsequent ATP-induced calcium release was almost completely absent at a 20 μM concentration of IP3K Inhibitor[1].
References	[1]. Chang YT, et al. Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase. Chembiochem. 2002 Sep 2;3(9):897-901.