Taurochenodeoxycholic acid

Modify Date: 2024-01-02 12:38:47

Taurochenodeoxycholic acid structure	Common Name	Taurochenodeoxycholic acid
	CAS Number	516-35-8	Molecular Weight	499.704
	Density	1.2±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₂₆H₄₅NO₆S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Taurochenodeoxycholic acid

Taurochenodeoxycholic acid is one of the main bioactive substances of animals' bile acid.

Name	taurochenodeoxycholic acid
Synonym	More Synonyms

Description	Taurochenodeoxycholic acid is one of the main bioactive substances of animals' bile acid.
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Signaling Pathways >> Apoptosis >> Caspase Signaling Pathways >> Apoptosis >> TNF Receptor Research Areas >> Inflammation/Immunology Natural Products >> Steroids
Target	Caspase TNF-α Human Endogenous Metabolite Apoptosis
In Vitro	Studies have suggested that taurochenodeoxycholic acid as a signaling molecule shows obvious anti-inflammatory and immune regulation properties. Taurochenodeoxycholic acid dramatically improves the apoptosis rate of NR8383 cells in a concentration-dependent manner. In the meantime, PKC mRNA levels and activities are significantly augmented by taurochenodeoxycholic acid treatments. In addition, JNK, caspase-3 and caspase-8 mRNA expression levels and activities are increased by taurochenodeoxycholic acid[1].
In Vivo	Taurochenodeoxycholic acid in dosages of 0.05 and 0.1g/kg can decrease the pulmonary coefficient in the model mice, taurochenodeoxycholic acid in dosages of 0.05 and 0.1g/kg reduce the pathological damages on their lungs; it can decrease the expression levels of TNF-α and TIMP-2 in pulmonary tissues in the pulmonary fibrosis mice, the expression level of MMP-9 increases, while it has no significant effects on MMP2[2]. Taurochenodeoxycholic acid significantly normalizes the clinical inflammatory parameters, prevented indomethacin-induced increases in the biliary contents of secondary bile acids and hydrophobicity index, and tended to attenuate the intestinal inflammation[3]. Taurochenodeoxycholic acid significantly suppresses paw swelling and polyarthritis index, increases the loss body weight and index of thymus and spleen, and amends radiologic changes in AA rats. The overproduction and mRNA expression of TNF-α, IL-1β and IL-6 are remarkably suppressed in serum and synovium tissue of all TCDCA-treated rats[4].
Animal Admin	Rats: Male Wistar rats are divided into six groups of ten each. Group 1 is normal rat (Sham), Group 2 received FCA only, Group 3 and Group 4 received FCA+Taurochenodeoxycholic acid (0.1 g/kg) and FCA+Taurochenodeoxycholic acid (0.2 g/kg), respectively, Groups 3 and 4 are treated beginning from day 0 of injection of FCA, Group 5 and Group 6 received FCA+Taurochenodeoxycholic acid (0.1 g/kg) and FCA+Taurochenodeoxycholic acid (0.2 g/kg), respectively, Group 5 and Group 6 are treated from 14 days after induction. All animals are treated with intragastrical administration and sacrificed after 28 days of induction[4].
References	[1]. Wang X, et al. Taurochenodeoxycholic acid induces NR8383 cells apoptosis via PKC/JNK-dependent pathway. Eur J Pharmacol. 2016 Sep 5;786:109-15. [2]. Zhou C, et al. The effects of taurochenodeoxycholic acid in preventing pulmonary fibrosis in mice. Pak J Pharm Sci. 2013 Jul;26(4):761-5. [3]. Uchida A, et al. Taurochenodeoxycholic acid ameliorates and ursodeoxycholic acid exacerbates small intestinal inflammation. Am J Physiol. 1997 May;272(5 Pt 1):G1249-57. [4]. Liu M, et al. Effects of taurochenodeoxycholic acid on adjuvant arthritis in rats. Int Immunopharmacol. 2011 Dec;11(12):2150-8.

Density	1.2±0.1 g/cm3
Molecular Formula	C₂₆H₄₅NO₆S
Molecular Weight	499.704
Exact Mass	499.296753
PSA	132.31000
LogP	2.10
Index of Refraction	1.552
Storage condition	-20°C

Precursor 2
CAS#:35807-85-3 Sodium taurours... CAS#:107-35-7 Taurine
DownStream 0

Chenyltaurine

2-{[(3α,5β,7α,8ξ,9ξ,14ξ)-3,7-Dihydroxy-24-oxocholan-24-yl]amino}ethanesulfonic acid

Chenodeoxycholyltaurine

Chenodeoxytaurocholic acid

12-Deoxycholyltaurine

Ethanesulfonic acid, 2-[[(3α,5β,7α,8ξ,9ξ,14ξ)-3,7-dihydroxy-24-oxocholan-24-yl]amino]-

Chenodeoxycholoyltaurine

[3H]-Chenodeoxycholyltaurine

Taurochenodeoxycholic acid

12-Desoxycholyltaurine

Taurochenodesoxycholic acid

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Taurochenodeoxycholic acid
Price: ￥238.0/20mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Taurochenodeoxycholic Acid
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: TAUROCHENODESOXYCHOLIC ACID
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Taurochenodeoxycholic acid
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

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