Amcinonide
Modify Date: 2024-01-02 17:22:47
Amcinonide structure
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Common Name | Amcinonide | ||
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| CAS Number | 51022-69-6 | Molecular Weight | 502.57200 | |
| Density | 1.33 g/cm3 | Boiling Point | 635.9ºC at 760 mmHg | |
| Molecular Formula | C28H35FO7 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 338.4ºC | |
Use of AmcinonideAmcinonide inhibit NO release from activated microglia with IC50 3.38 nM. Amcinonide has affinity for the glucocorticoid receptor.IC50 value: 3.38 nM [1]Target: NO releasein vitro: Simultaneous immunofluorescent staining for T6 and Ia antigenicity within human epidermis of Amcinonide treated skin detected reduced numbers of T6+/Ia+ cells with a concomitant increase in T6+/Ia- cells. [2]in vivo: Amcinonide is an anti-inflammatory agent, elicites whitening of a few hairs in both pheomelanic and eumelanic mice. Amcinonide brings about a marked reduction in the numbers of DOPA-positive epidermal melanocytes inhabiting the tails of eumelanic or pheomelanic mice. Amcinonide exertes a deleterious influence on the structure and function of tail epidermis. [3] |
| Name | amcinonide |
|---|---|
| Synonym | More Synonyms |
| Description | Amcinonide inhibit NO release from activated microglia with IC50 3.38 nM. Amcinonide has affinity for the glucocorticoid receptor.IC50 value: 3.38 nM [1]Target: NO releasein vitro: Simultaneous immunofluorescent staining for T6 and Ia antigenicity within human epidermis of Amcinonide treated skin detected reduced numbers of T6+/Ia+ cells with a concomitant increase in T6+/Ia- cells. [2]in vivo: Amcinonide is an anti-inflammatory agent, elicites whitening of a few hairs in both pheomelanic and eumelanic mice. Amcinonide brings about a marked reduction in the numbers of DOPA-positive epidermal melanocytes inhabiting the tails of eumelanic or pheomelanic mice. Amcinonide exertes a deleterious influence on the structure and function of tail epidermis. [3] |
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| Related Catalog | |
| References |
| Density | 1.33 g/cm3 |
|---|---|
| Boiling Point | 635.9ºC at 760 mmHg |
| Molecular Formula | C28H35FO7 |
| Molecular Weight | 502.57200 |
| Flash Point | 338.4ºC |
| Exact Mass | 502.23700 |
| PSA | 99.13000 |
| LogP | 3.52380 |
| Index of Refraction | 1.586 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Hazard Codes | Xn |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | TU3682500 |
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Contact allergy to amcinonide.
Contact Dermatitis 15(2) , 109-11, (1986)
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Trypsin inhibitors inhibit induction by interferon-gamma of HLA-DR antigen expression on human skin cells.
Exp. Cell Res. 183(1) , 215-28, (1989) Serine protease inhibitors with a specificity for trypsin inhibit interferon-gamma (INF-gamma)-induced HLA-DR expression on a hybrid human epidermal cell line (H12), dermal fibroblasts, and primary ke... |
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Selective corticosteroid injection into the extensor pollicis brevis tenosynovium for de Quervain's disease.
Orthopedics 25(1) , 68-70, (2002) Selective corticosteroid injection into the extensor pollicis brevis tenosynovium was performed in 50 patients (7 men and 43 women; 53 hands) with de Quervain's disease. Mean patient age was 32.4 year... |
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| AMCINONIDE |