Rotenolone

Modify Date: 2024-01-03 09:38:10

Rotenolone Structure
Rotenolone structure
Common Name Rotenolone
CAS Number 509-96-6 Molecular Weight 410.417
Density 1.4±0.1 g/cm3 Boiling Point 623.1±55.0 °C at 760 mmHg
Molecular Formula C23H22O7 Melting Point N/A
MSDS N/A Flash Point 219.2±25.0 °C

 Use of Rotenolone


Rotenolone is an antiproliferative agent. Rotenolone shows antiproliferative activity against the ovarian cancer A2780, breast cancer BT-549, prostate cancer DU 145, NSCLC NCI-H460, and colon cancer HCC-2998 cell lines, with IC50s of 0.95, 1.6, 2.7, 2.0, and 2.9 μM, respectively[1].

 Names

Name 12alpha-HYDROXYROTENONE
Synonym More Synonyms

 Rotenolone Biological Activity

Description Rotenolone is an antiproliferative agent. Rotenolone shows antiproliferative activity against the ovarian cancer A2780, breast cancer BT-549, prostate cancer DU 145, NSCLC NCI-H460, and colon cancer HCC-2998 cell lines, with IC50s of 0.95, 1.6, 2.7, 2.0, and 2.9 μM, respectively[1].
Related Catalog
References

[1]. Harinantenaina L, et, al. Antiproliferative compounds from Pongamiopsis pervilleana from the Madagascar Dry Forest. J Nat Prod. 2010 Sep 24;73(9):1559-62.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 623.1±55.0 °C at 760 mmHg
Molecular Formula C23H22O7
Molecular Weight 410.417
Flash Point 219.2±25.0 °C
Exact Mass 410.136566
LogP 4.11
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.622
Storage condition -20°C

 Safety Information

Hazard Codes Xn

 Synonyms

Furo[2',3':7,8][1]benzopyrano[2,3-c][1]benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-6a-hydroxy-8,9-dimethoxy-2-(1-methylethenyl)-, (2R,6aR,12aR)-
(2R,6aR,12aR)-6a-hydroxy-8,9-dimethoxy-2-(prop-1-en-2-yl)-1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one
[1]Benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-6a-hydroxy-8,9-dimethoxy-2-(1-methylethenyl)-, (2R,6aR,12aR)-
12a-Hydroxyrotenone
(2R,6aR,12aR)-6a-Hydroxy-2-isopropenyl-8,9-dimethoxy-1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one
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