Aβ42 agonist-1

Modify Date: 2022-01-24 19:05:57

Aβ42 agonist-1 Structure
Aβ42 agonist-1 structure
Common Name Aβ42 agonist-1
CAS Number 50635-12-6 Molecular Weight 237.25300
Density N/A Boiling Point N/A
Molecular Formula C15H11NO2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Aβ42 agonist-1


Aβ42 agonist-1 (compound 7a) is a small molecule compound that can promote Aβ42 aggregation. Aβ42 agonist-1 can interact with Aβ42 oligomers and pentamers to promote nontoxic aggregate self-assembly and rapid fibril formation. Aβ42 agonist-1 prevents Aβ42-induced cytotoxicity in HT22 hippocampal neuronal cells[1].

 Names

Name benzofuran-2-carboxylic acid N-phenylamide
Synonym More Synonyms

 Aβ42 agonist-1 Biological Activity

Description Aβ42 agonist-1 (compound 7a) is a small molecule compound that can promote Aβ42 aggregation. Aβ42 agonist-1 can interact with Aβ42 oligomers and pentamers to promote nontoxic aggregate self-assembly and rapid fibril formation. Aβ42 agonist-1 prevents Aβ42-induced cytotoxicity in HT22 hippocampal neuronal cells[1].
Related Catalog
Target

Aβ42 aggregation[1]

References

[1]. Zhao Y et al. Small Molecules N-Phenylbenzofuran-2-carboxamide and N-Phenylbenzo[b]thiophene-2-carboxamide Promote Beta-Amyloid (Aβ42) Aggregation and Mitigate Neurotoxicity. ACS Chem Neurosci. 2023 Nov 16.  

 Chemical & Physical Properties

Molecular Formula C15H11NO2
Molecular Weight 237.25300
Exact Mass 237.07900
PSA 42.24000
LogP 3.75810

 Precursor & DownStream

Precursor  0

DownStream  1

 Synonyms

benzofuran-2-carboxylic acid anilide
Benzofuran-2-carbonsaeure-anilid
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