50635-12-6

50635-12-6 structure

Name: Aβ42 agonist-1
Chemical Name: benzofuran-2-carboxylic acid N-phenylamide
CAS Number: 50635-12-6
Molecular Formula: C₁₅H₁₁NO₂
Molecular Weight: 237.25300
Catalog: Research Areas Neurological Disease
Create Date: 2016-08-25 11:54:17
Modify Date: 2022-01-24 19:05:57
Aβ42 agonist-1 (compound 7a) is a small molecule compound that can promote Aβ42 aggregation. Aβ42 agonist-1 can interact with Aβ42 oligomers and pentamers to promote nontoxic aggregate self-assembly and rapid fibril formation. Aβ42 agonist-1 prevents Aβ42-induced cytotoxicity in HT22 hippocampal neuronal cells[1].

Name	benzofuran-2-carboxylic acid N-phenylamide
Synonyms	benzofuran-2-carboxylic acid anilide Benzofuran-2-carbonsaeure-anilid

Description	Aβ42 agonist-1 (compound 7a) is a small molecule compound that can promote Aβ42 aggregation. Aβ42 agonist-1 can interact with Aβ42 oligomers and pentamers to promote nontoxic aggregate self-assembly and rapid fibril formation. Aβ42 agonist-1 prevents Aβ42-induced cytotoxicity in HT22 hippocampal neuronal cells[1].
Related Catalog	Research Areas >> Neurological Disease
Target	Aβ42 aggregation[1]
References	[1]. Zhao Y et al. Small Molecules N-Phenylbenzofuran-2-carboxamide and N-Phenylbenzo[b]thiophene-2-carboxamide Promote Beta-Amyloid (Aβ42) Aggregation and Mitigate Neurotoxicity. ACS Chem Neurosci. 2023 Nov 16.

Precursor 0
DownStream 1
4265-16-1