8-Benzyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one

Modify Date: 2025-08-24 23:36:14

8-Benzyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one Structure
8-Benzyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one structure
 Common Name 8-Benzyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one
CAS Number 5053-14-5 Molecular Weight 246.30500
Density 1.22g/cm3 Boiling Point 457.1ºC at 760 mmHg
Molecular Formula C14H18N2O2 Melting Point N/A
MSDS N/A Flash Point 230.2ºC

 Names

Name 8-Benzyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.22g/cm3
Boiling Point 457.1ºC at 760 mmHg
Molecular Formula C14H18N2O2
Molecular Weight 246.30500
Flash Point 230.2ºC
Exact Mass 246.13700
PSA 45.06000
LogP 1.33890
Index of Refraction 1.6

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RO0220000
CHEMICAL NAME :
1-Oxa-3,8-diazaspiro(4.5)decan-2-one, 8-benzyl-
CAS REGISTRY NUMBER :
5053-14-5
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C14-H18-N2-O2
MOLECULAR WEIGHT :
246.34
WISWESSER LINE NOTATION :
T6N CXTJ A1R& C-& DT5MVOX EHJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
319 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CHTPBA Chimica Therapeutica. (Paris, France) V.1-8, 1965-73. For publisher information, see EJMCA5. Volume(issue)/page/year: 4,185,1969

 Safety Information

HS Code 2934999090

 Synthetic Route

4-(Aminomethyl)-1-benzyl-4-piperidinol structure

4-(Aminomethyl)...

CAS#:23804-68-4

~%

8-Benzyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one Structure

8-Benzyl-1-oxa-...

CAS#:5053-14-5

Literature: Merck and Co., Inc. Patent: US6172076 B2, 2001 ; US 6172076 B1
2-(1-benzyl-4-hydroxypiperidin-4-yl)acetohydrazide structure

2-(1-benzyl-4-h...

CAS#:77211-73-5

~%

8-Benzyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one Structure

8-Benzyl-1-oxa-...

CAS#:5053-14-5

Literature: Caroon; Clark; Kluge; Nelson; Strosberg; Unger; Michel; Whiting Journal of Medicinal Chemistry, 1981 , vol. 24, # 11 p. 1320 - 1328
Triphosgene structure

Triphosgene

CAS#:32315-10-9

4-(Aminomethyl)-1-benzyl-4-piperidinol structure

4-(Aminomethyl)...

CAS#:23804-68-4

~74%

8-Benzyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one Structure

8-Benzyl-1-oxa-...

CAS#:5053-14-5

Literature: Somanathan; Rivero; Nunez; Hellberg Synthetic Communications, 1994 , vol. 24, # 10 p. 1483 - 1487
1-benzyl-4-cyano-4-hydroxypiperidine structure

1-benzyl-4-cyan...

CAS#:6094-60-6

~%

8-Benzyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one Structure

8-Benzyl-1-oxa-...

CAS#:5053-14-5

Literature: Methot, Joey L.; Hoffman, Dawn Mampreian; Witter, David J.; Stanton, Matthew G.; Harrington, Paul; Hamblett, Christopher; Siliphaivanh, Phieng; Wilson, Kevin; Hubbs, Jed; Heidebrecht, Richard; Kral, Astrid M.; Ozerova, Nicole; Fleming, Judith C.; Wang, Hongmei; Szewczak, Alexander A.; Middleton, Richard E.; Hughes, Bethany; Cruz, Jonathan C.; Haines, Brian B.; Chenard, Melissa; Kenific, Candia M.; Harsch, Andreas; Secrist, J. Paul; Miller, Thomas A. ACS Medicinal Chemistry Letters, 2014 , vol. 5, # 4 p. 340 - 345
N-Benzyl-4-piperidone structure

N-Benzyl-4-pipe...

CAS#:3612-20-2

~%

8-Benzyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one Structure

8-Benzyl-1-oxa-...

CAS#:5053-14-5

Literature: Somanathan; Rivero; Nunez; Hellberg Synthetic Communications, 1994 , vol. 24, # 10 p. 1483 - 1487
1-Benzyl-4-((trimethylsilyl)oxy)piperidine-4-carbonitrile structure

1-Benzyl-4-((tr...

CAS#:156215-49-5

~%

8-Benzyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one Structure

8-Benzyl-1-oxa-...

CAS#:5053-14-5

Literature: Somanathan; Rivero; Nunez; Hellberg Synthetic Communications, 1994 , vol. 24, # 10 p. 1483 - 1487
4-(Aminomethyl)-1-benzyl-4-piperidinol structure

4-(Aminomethyl)...

CAS#:23804-68-4

Ethyl carbonate structure

Ethyl carbonate

CAS#:105-58-8

~%

8-Benzyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one Structure

8-Benzyl-1-oxa-...

CAS#:5053-14-5

Literature: Regnier,G. et al. Chimica Therapeutica, 1969 , vol. 4, p. 185 - 194
4-(Aminomethyl)-1-benzyl-4-piperidinol structure

4-(Aminomethyl)...

CAS#:23804-68-4

N,N-Carbonyldiimidazole structure

N,N-Carbonyldii...

CAS#:530-62-1

~%

8-Benzyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one Structure

8-Benzyl-1-oxa-...

CAS#:5053-14-5

Literature: Methot, Joey L.; Hoffman, Dawn Mampreian; Witter, David J.; Stanton, Matthew G.; Harrington, Paul; Hamblett, Christopher; Siliphaivanh, Phieng; Wilson, Kevin; Hubbs, Jed; Heidebrecht, Richard; Kral, Astrid M.; Ozerova, Nicole; Fleming, Judith C.; Wang, Hongmei; Szewczak, Alexander A.; Middleton, Richard E.; Hughes, Bethany; Cruz, Jonathan C.; Haines, Brian B.; Chenard, Melissa; Kenific, Candia M.; Harsch, Andreas; Secrist, J. Paul; Miller, Thomas A. ACS Medicinal Chemistry Letters, 2014 , vol. 5, # 4 p. 340 - 345

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

8-benzyl-1-oxa-2-oxo-3,8-diazospiro<4,5>decane
8-benzyl-1-oxa-3,8-diazaspiro<4.5>decan-2-one
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Chemsrc provides CAS#:5053-14-5 MSDS, density, melting point, boiling point, structure, etc. Its name is 8-Benzyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one>> amp version: 8-Benzyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one

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