(±)-Metanephrine

Modify Date: 2024-01-10 17:42:34

(±)-Metanephrine Structure
(±)-Metanephrine structure
Common Name (±)-Metanephrine
CAS Number 5001-33-2 Molecular Weight 197.231
Density 1.2±0.1 g/cm3 Boiling Point 378.8±42.0 °C at 760 mmHg
Molecular Formula C10H15NO3 Melting Point 180-182ºC
MSDS N/A Flash Point 182.9±27.9 °C

 Use of (±)-Metanephrine


Metanephrine is the O-methylated metabolite of epinephrine that can be used for the research of diagnosis of pheochromocytoma[1].

 Names

Name 4-[1-hydroxy-2-(methylamino)ethyl]-2-methoxyphenol
Synonym More Synonyms

 (±)-Metanephrine Biological Activity

Description Metanephrine is the O-methylated metabolite of epinephrine that can be used for the research of diagnosis of pheochromocytoma[1].
Related Catalog
Target

Human Endogenous Metabolite

In Vitro Metanephrine inhibits MPP+ uptake into Caki-1 cells and rat hepatocytes with IC50s of 34.2 µM and 302.0 µM, respectively[2].
References

[1]. Eisenhofer G, et al. Measurements of plasma methoxytyramine, normetanephrine, and metanephrine as discriminators of different hereditary forms of pheochromocytoma. Clin Chem. 2011 Mar;57(3):411-20.  

[2]. Martel F, et al. Comparison between uptake2 and rOCT1: effects of catecholamines, metanephrines and corticosterone. Naunyn Schmiedebergs Arch Pharmacol. 1999 Apr;359(4):303-9.  

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 378.8±42.0 °C at 760 mmHg
Melting Point 180-182ºC
Molecular Formula C10H15NO3
Molecular Weight 197.231
Flash Point 182.9±27.9 °C
Exact Mass 197.105194
PSA 61.72000
LogP -0.32
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.557

 Synonyms

Metanephrine
DL-3-O-Methyladrenaline
3-O-Methylepinephrine
DL-methanephrine
4-Hydroxy-3-methoxy-a-(methylaminomethyl)benzenemethanol
3-O-methyl-Adrenaline
3-O-Methyladrenaline
DL-Metanephrine
1-(4-Hydroxy-3-melhoxyphenyl)-2-methylaminoethanol
Benzenemethanol, 4-hydroxy-3-methoxy-α-((methylamino)methyl)-
3-Methoxyadrenaline
metadrenaline
4-[1-Hydroxy-2-(methylamino)ethyl]-2-methoxyphenol
a-(Methylaminomethyl)vanillyl Alcohol
m-O-Methyladrenaline
Benzenemethanol, 4-hydroxy-3-methoxy-α-[(methylamino)methyl]-
methyladrenaline