5001-33-2

5001-33-2 structure

Name: (±)-Metanephrine
Chemical Name: 4-[1-hydroxy-2-(methylamino)ethyl]-2-methoxyphenol
CAS Number: 5001-33-2
Molecular Formula: C₁₀H₁₅NO₃
Molecular Weight: 197.231
Catalog: Research Areas Cancer
Create Date: 2018-04-07 08:00:00
Modify Date: 2024-01-10 17:42:34
Metanephrine is the O-methylated metabolite of epinephrine that can be used for the research of diagnosis of pheochromocytoma[1].

Name	4-[1-hydroxy-2-(methylamino)ethyl]-2-methoxyphenol
Synonyms	Metanephrine DL-3-O-Methyladrenaline 3-O-Methylepinephrine DL-methanephrine 4-Hydroxy-3-methoxy-a-(methylaminomethyl)benzenemethanol 3-O-methyl-Adrenaline 3-O-Methyladrenaline DL-Metanephrine 1-(4-Hydroxy-3-melhoxyphenyl)-2-methylaminoethanol Benzenemethanol, 4-hydroxy-3-methoxy-α-((methylamino)methyl)- 3-Methoxyadrenaline metadrenaline 4-[1-Hydroxy-2-(methylamino)ethyl]-2-methoxyphenol a-(Methylaminomethyl)vanillyl Alcohol m-O-Methyladrenaline Benzenemethanol, 4-hydroxy-3-methoxy-α-[(methylamino)methyl]- methyladrenaline

Description	Metanephrine is the O-methylated metabolite of epinephrine that can be used for the research of diagnosis of pheochromocytoma[1].
Related Catalog	Research Areas >> Cancer
Target	Human Endogenous Metabolite
In Vitro	Metanephrine inhibits MPP+ uptake into Caki-1 cells and rat hepatocytes with IC50s of 34.2 µM and 302.0 µM, respectively[2].
References	[1]. Eisenhofer G, et al. Measurements of plasma methoxytyramine, normetanephrine, and metanephrine as discriminators of different hereditary forms of pheochromocytoma. Clin Chem. 2011 Mar;57(3):411-20. [2]. Martel F, et al. Comparison between uptake2 and rOCT1: effects of catecholamines, metanephrines and corticosterone. Naunyn Schmiedebergs Arch Pharmacol. 1999 Apr;359(4):303-9.