(±)-Metanephrine

Names

[ Name ]:
(±)-Metanephrine

[Synonym ]:
Metanephrine
DL-3-O-Methyladrenaline
3-O-Methylepinephrine
DL-methanephrine
4-Hydroxy-3-methoxy-a-(methylaminomethyl)benzenemethanol
3-O-methyl-Adrenaline
3-O-Methyladrenaline
DL-Metanephrine
1-(4-Hydroxy-3-melhoxyphenyl)-2-methylaminoethanol
Benzenemethanol, 4-hydroxy-3-methoxy-α-((methylamino)methyl)-
3-Methoxyadrenaline
metadrenaline
4-[1-Hydroxy-2-(methylamino)ethyl]-2-methoxyphenol
a-(Methylaminomethyl)vanillyl Alcohol
m-O-Methyladrenaline
Benzenemethanol, 4-hydroxy-3-methoxy-α-[(methylamino)methyl]-
methyladrenaline

Biological Activity

[Description]:

Metanephrine is the O-methylated metabolite of epinephrine that can be used for the research of diagnosis of pheochromocytoma[1].

[Related Catalog]:

Research Areas >> Cancer

[Target]

Human Endogenous Metabolite

[In Vitro]

Metanephrine inhibits MPP+ uptake into Caki-1 cells and rat hepatocytes with IC50s of 34.2 µM and 302.0 µM, respectively[2].

[References]

[1]. Eisenhofer G, et al. Measurements of plasma methoxytyramine, normetanephrine, and metanephrine as discriminators of different hereditary forms of pheochromocytoma. Clin Chem. 2011 Mar;57(3):411-20.

[2]. Martel F, et al. Comparison between uptake2 and rOCT1: effects of catecholamines, metanephrines and corticosterone. Naunyn Schmiedebergs Arch Pharmacol. 1999 Apr;359(4):303-9.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
378.8±42.0 °C at 760 mmHg

[ Melting Point ]:
180-182ºC

[ Molecular Formula ]:
C₁₀H₁₅NO₃

[ Molecular Weight ]:
197.231

[ Flash Point ]:
182.9±27.9 °C

[ Exact Mass ]:
197.105194

[ PSA ]:
61.72000

[ LogP ]:
-0.32

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.557

Related Compounds

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