chlorantraniliprole

Modify Date: 2024-01-01 19:25:49

chlorantraniliprole Structure
chlorantraniliprole structure
 Common Name chlorantraniliprole
CAS Number 500008-45-7 Molecular Weight 483.146
Density 1.7±0.1 g/cm3 Boiling Point 526.6±50.0 °C at 760 mmHg
Molecular Formula C18H14BrCl2N5O2 Melting Point 208 - 210 °C
MSDS Chinese USA Flash Point 272.3±30.1 °C
Symbol GHS07 GHS09
GHS07, GHS09		 Signal Word Warning

 Use of chlorantraniliprole


Chlorantraniliprole is an insecticide that potently and selectively activates insect ryanodine receptor, with EC50s of 40 nM and 50 nM for Drosophila melanogaster and H. virescens ryanodine receptor, and ∼300-fold more potent than that in the mouse myoblast cell line, C2C12 (EC50, 14 μM).

 Names

Name chlorantraniliprole
Synonym More Synonyms

 chlorantraniliprole Biological Activity

Description Chlorantraniliprole is an insecticide that potently and selectively activates insect ryanodine receptor, with EC50s of 40 nM and 50 nM for Drosophila melanogaster and H. virescens ryanodine receptor, and ∼300-fold more potent than that in the mouse myoblast cell line, C2C12 (EC50, 14 μM).
Related Catalog
Target

EC50: 40 nM (Drosophila melanogaster Ryanodine receptor), 50 nM (H. virescens Ryanodine receptor), 14 μM (Ryanodine receptor, in C2C12 cells)
In Vitro Chlorantraniliprole is an insecticide that potently and selectively activates insect ryanodine receptor. Chlorantraniliprole actions by release of intracellular Ca2+ stores mediated by the ryanodine receptor. Chlorantraniliprole is ∼300-fold less potent against ryanodine receptor (RyRs) in the mouse myoblast cell line, C2C12 (EC50, 14 μM), than in insect RyRs from Drosophila melanogaster and H. virescens (EC50, 40 nM, 50 nM), and shows little selectivity at the rat cell line RyR2 (EC50, >100 μM)[1].
In Vivo Chlorantraniliprole has low acute mammalian toxicity with an acute oral LD50 of >5000 mg/kg in rats, and little to no toxicity in 90-day studies, at dosing as high as 1500 mg/kg/day[1].
References

[1]. George P.Lahm, et al. Rynaxypyr: A new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator. Bioorganic & Medicinal Chemistry Letters. 2007 Nov 15;17(22):6274-6279.

 Chemical & Physical Properties

Density 1.7±0.1 g/cm3
Boiling Point 526.6±50.0 °C at 760 mmHg
Melting Point 208 - 210 °C
Molecular Formula C18H14BrCl2N5O2
Molecular Weight 483.146
Flash Point 272.3±30.1 °C
Exact Mass 480.970795
PSA 88.91000
LogP 5.55
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.699

 Safety Information

Symbol GHS07 GHS09
GHS07, GHS09
Signal Word Warning
Hazard Statements H315-H319-H335-H400
Precautionary Statements P273-P280-P304 + P340 + P312-P305 + P351 + P338-P337 + P313-P391
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn
Risk Phrases 22-36/37
Safety Phrases 26
RIDADR UN 3077 9 / PGIII
HS Code 2933399021

 Customs

HS Code 2933399021
Summary 2933399021 (r)-2-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenoxy)propanoic acid。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%

 Synonyms

3-bromo-N-[4-chloro-2-methyl-6-(methylcarbamoyl)phenyl]-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide
3-bromo-4’-chloro-1-(3-chloro-2-pyridyl)-2’-methyl-6’-(methylcarbamoyl)pyrazole-5-carboxanilide
3-Bromo-N-[4-chloro-2-methyl-6-[(methylamino)carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide
Chlorantraniliprole
3-bromo-N-[4-chloro-2-methyl-6-[(methylamino)carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide
DPX E2Y45
5-bromo-N-[4-chloro-2-methyl-6-(methylcarbamoyl)phenyl]-2-(3-chloropyridin-2-yl)pyrazole-3-carboxamide
Chlorantranilipol
CHLOANTRANILIPROLE
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Related Compounds: More...
Chlorantraniliprole-(N-methyl-d3)
1392493-28-5
Chemsrc provides chlorantraniliprole(CAS#:500008-45-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of chlorantraniliprole are included as well.>> amp version: chlorantraniliprole

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