g418

Modify Date: 2024-01-08 17:40:09

g418 structure	Common Name	g418
	CAS Number	49863-47-0	Molecular Weight	496.55200
	Density	1.47 g/cm3	Boiling Point	760.3ºC at 760 mmHg
	Molecular Formula	C₂₀H₄₀N₄O₁₀	Melting Point	N/A
	MSDS	N/A	Flash Point	413.6ºC

Use of g418

G-418 (Geneticin) is an aminoglycoside antibiotic with a structure similar to gentamicin. It is toxic to both eukaryotic and prokaryotic cells and works by interfering with protein synthesis[1].

Name	geneticin
Synonym	More Synonyms

Description	G-418 (Geneticin) is an aminoglycoside antibiotic with a structure similar to gentamicin. It is toxic to both eukaryotic and prokaryotic cells and works by interfering with protein synthesis[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	G-418 (500 μg/mL，12 days) 用于筛选耐药性 LNCaP 细胞[1]。
References	[1]. S Bennett, et al. Reliable method of isolating transfected clones from the LNCaP human prostatic cell line. Biotechniques. 1997 Jul;23(1):66, 68, 70.

Density	1.47 g/cm3
Boiling Point	760.3ºC at 760 mmHg
Molecular Formula	C₂₀H₄₀N₄O₁₀
Molecular Weight	496.55200
Flash Point	413.6ºC
Exact Mass	496.27400
PSA	248.39000
Storage condition	2-8°C
Water Solubility	H2O: 50 mg/mL

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WK2132600

CHEMICAL NAME :: D-Streptamine, O-2-amino-2,7-dideoxy-D-glycero-alpha-D-gluco-heptopy ranosyl-(1-4)-O- (3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyr anosyl-(1-6))-

CAS REGISTRY NUMBER :: 49863-47-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C20-H40-N4-O10

MOLECULAR WEIGHT :: 496.64

WISWESSER LINE NOTATION :: T6OTJ CZ DQ EQ FYQ1 BO- BL6TJ AZ CQ EZ DO- BT6OTJ CQ DM1 EQ E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 140 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Fibroblast

DOSE/DURATION :: 75 mg/L

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 21,67,1993

Hazard Codes	Xn: Harmful;
Risk Phrases	R20/21/22
Safety Phrases	22-24/25
WGK Germany	3

Gentamicin G-418

Gentamycin B

(2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-[(1R)-1-hydroxyethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol

Betamicina [INN-Spanish]

Gentamicin B

Betamicina

BETAMICIN

Betamicinum [INN-Latin]

Betamicine [INN-French]

Betamicin [INN]

g418

Use of g418

Names

g418 Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Synonyms