EN460
Modify Date: 2025-08-21 11:13:29
EN460 structure
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Common Name | EN460 | ||
|---|---|---|---|---|
| CAS Number | 496807-64-8 | Molecular Weight | 460.79 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H12ClF3N2O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of EN460EN460 is a small molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1); interacts selectively(IC50=1.9 uM) with the reduced, active form of ERO1α and prevents its reoxidation.IC50 value: 1.9 uM [1]Target: ERO1 inhibitorin vitro: Exposure of cells to EN460 or QM295 resulted in the accumulation of an ERO1α form with lower mobility, indicative of the reduced state. EN460 and QM295 were also found to activate an unfolded protein response reporter in cultured 293T cells. |
| Name | en460 |
|---|
| Description | EN460 is a small molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1); interacts selectively(IC50=1.9 uM) with the reduced, active form of ERO1α and prevents its reoxidation.IC50 value: 1.9 uM [1]Target: ERO1 inhibitorin vitro: Exposure of cells to EN460 or QM295 resulted in the accumulation of an ERO1α form with lower mobility, indicative of the reduced state. EN460 and QM295 were also found to activate an unfolded protein response reporter in cultured 293T cells. |
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| Related Catalog | |
| References |
| Molecular Formula | C22H12ClF3N2O4 |
|---|---|
| Molecular Weight | 460.79 |
| PSA | 56.40000 |
| LogP | 3.28560 |
| Storage condition | 2-8℃ |