496807-64-8

496807-64-8 structure

Name: EN460
Chemical Name: en460
CAS Number: 496807-64-8
Molecular Formula: C₂₂H₁₂ClF₃N₂O₄
Molecular Weight: 460.79
Catalog: Research Areas Others
Create Date: 2017-07-22 23:15:07
Modify Date: 2025-08-21 11:13:29
EN460 is a small molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1); interacts selectively(IC50=1.9 uM) with the reduced, active form of ERO1α and prevents its reoxidation.IC50 value: 1.9 uM [1]Target: ERO1 inhibitorin vitro: Exposure of cells to EN460 or QM295 resulted in the accumulation of an ERO1α form with lower mobility, indicative of the reduced state. EN460 and QM295 were also found to activate an unfolded protein response reporter in cultured 293T cells.

Name	en460

Description	EN460 is a small molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1); interacts selectively(IC50=1.9 uM) with the reduced, active form of ERO1α and prevents its reoxidation.IC50 value: 1.9 uM [1]Target: ERO1 inhibitorin vitro: Exposure of cells to EN460 or QM295 resulted in the accumulation of an ERO1α form with lower mobility, indicative of the reduced state. EN460 and QM295 were also found to activate an unfolded protein response reporter in cultured 293T cells.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others
References	[1]. Blais JD, et al. A small molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1) with selectively reversible thiol reactivity. J Biol Chem. 2010 Jul 2;285(27):20993-1003.