MRS 2395
Modify Date: 2024-01-14 16:11:21
MRS 2395 structure
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Common Name | MRS 2395 | ||
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| CAS Number | 491611-55-3 | Molecular Weight | 439.93600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H30ClN5O4 | Melting Point | N/A | |
| MSDS | Chinese | Flash Point | N/A | |
Use of MRS 2395MRS2395, an dipivaloyl derivative, is a potent P2Y12 receptor antagonist. MRS2395 inhibits ADP-induced platelet activation with a Ki of 3.6 μM. MRS2395 inhibits cAMP induced by ADP in rat platelets in the presence of PGE1 with an IC50 of 7 µM. MRS2395 enhances platelet dense granule release in response to TRAP-6[1][2]. |
| Name | [2-[[2-chloro-6-(methylamino)purin-9-yl]methyl]-3-(2,2-dimethylpropanoyloxy)propyl] 2,2-dimethylpropanoate |
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| Synonym | More Synonyms |
| Description | MRS2395, an dipivaloyl derivative, is a potent P2Y12 receptor antagonist. MRS2395 inhibits ADP-induced platelet activation with a Ki of 3.6 μM. MRS2395 inhibits cAMP induced by ADP in rat platelets in the presence of PGE1 with an IC50 of 7 µM. MRS2395 enhances platelet dense granule release in response to TRAP-6[1][2]. |
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| Related Catalog | |
| References |
| Molecular Formula | C20H30ClN5O4 |
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| Molecular Weight | 439.93600 |
| Exact Mass | 439.19900 |
| PSA | 108.23000 |
| LogP | 3.38920 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
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Acyclic analogues of adenosine bisphosphates as P2Y receptor antagonists: phosphate substitution leads to multiple pathways of inhibition of platelet aggregation.
J. Med. Chem. 45 , 5694-5709, (2002) Activation by ADP of both P2Y(1) and P2Y(12) receptors in platelets contributes to platelet aggregation, and antagonists at these receptor subtypes have antithrombotic properties. In an earlier public... |
| 2,2-dimethyl-propionic acid 3-(2-chloro-6-methylaminopurin-9-yl)-2-(2,2-dimethyl-propionyloxymethyl)-propyl ester |
| 2,2-dimethyl-propanoic acid 3-(2-chloro-6-methylaminopurin-9-yl)-2-(2,2-dimethyl-propionyloxymethyl)-propyl ester |
| mrs 2395 |