(N,N,O-2H3)Glycine

Modify Date: 2024-01-09 08:38:00

(N,N,O-2H3)Glycine Structure
(N,N,O-2H3)Glycine structure
Common Name (N,N,O-2H3)Glycine
CAS Number 4896-76-8 Molecular Weight 78.09
Density 1.3±0.1 g/cm3 Boiling Point 240.9±23.0 °C at 760 mmHg
Molecular Formula C2H2D3NO2 Melting Point 240ºC (dec.)(lit.)
MSDS Chinese USA Flash Point 99.5±22.6 °C

 Use of (N,N,O-2H3)Glycine


Glycine-d3 is the deuterium labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

 Names

Name deuterio 2-(dideuterioamino)acetate
Synonym More Synonyms

 (N,N,O-2H3)Glycine Biological Activity

Description Glycine-d3 is the deuterium labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Johnson JW, et al. Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature. 1987 Feb 5-11;325(6104):529-31.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 240.9±23.0 °C at 760 mmHg
Melting Point 240ºC (dec.)(lit.)
Molecular Formula C2H2D3NO2
Molecular Weight 78.09
Flash Point 99.5±22.6 °C
Exact Mass 78.050858
PSA 63.32000
LogP -1.03
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.461

 Safety Information

RIDADR NONH for all modes of transport

 Synthetic Route

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(N,N,O-2H3)Glycine Structure

(N,N,O-2H3)Glycine

CAS#:4896-76-8

Literature: Mueller, Carmen; Schajor, W.; Zimmermann, H.; Haeberlen, U. Journal of Magnetic Resonance (1969-1992), 1984 , vol. 56, # 2 p. 235 - 246

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(N,N,O-2H3)Glycine Structure

(N,N,O-2H3)Glycine

CAS#:4896-76-8

Literature: Crugeiras, Juan; Rios, Ana; Riveiros, Enrique; Richard, John P. Journal of the American Chemical Society, 2011 , vol. 133, # 9 p. 3173 - 3183

 Precursor & DownStream

Precursor  1

DownStream  1

 Synonyms

N,N,O-trideuterio-glycine
N,N,1-Trideutero-glycin
Glycine-N,N,1-d
glycine-N,N,O-d3
N,N,O-Trideuterio-glycin
N,N,O-d3-glycine
(N,N,O-H)Glycine
MFCD00074933