Apovincamine
Apovincamine structure
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Common Name | Apovincamine | ||
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| CAS Number | 4880-92-6 | Molecular Weight | 336.42700 | |
| Density | 1.3g/cm3 | Boiling Point | 405.7ºC at 760mmHg | |
| Molecular Formula | C21H24N2O2 | Melting Point | 160-162℃ | |
| MSDS | N/A | Flash Point | 199.1ºC | |
Use of ApovincamineApovincamine (cis-Apovincamine) is an indole alkaloid isolated from the Malaysian Alstonia pneumatophora (Apocynaceae). Apovincamine shows anti-melanogenesis activity[1]. |
| Name | Apovincamine |
|---|---|
| Synonym | More Synonyms |
| Description | Apovincamine (cis-Apovincamine) is an indole alkaloid isolated from the Malaysian Alstonia pneumatophora (Apocynaceae). Apovincamine shows anti-melanogenesis activity[1]. |
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| Related Catalog | |
| In Vitro | Apovincamine (cis-Apovincamine; 6.3, 12.5, 25, 50, 100 μM) dose-dependently inhibits cells viability with an IC50 of 49.8 μM and shows anti-melanogenesis in B16 mouse melanoma cells[1]. |
| References |
| Density | 1.3g/cm3 |
|---|---|
| Boiling Point | 405.7ºC at 760mmHg |
| Melting Point | 160-162℃ |
| Molecular Formula | C21H24N2O2 |
| Molecular Weight | 336.42700 |
| Flash Point | 199.1ºC |
| Exact Mass | 336.18400 |
| PSA | 34.47000 |
| LogP | 3.69610 |
| Index of Refraction | 1.678 |
| InChIKey | OZDNDGXASTWERN-CTNGQTDRSA-N |
| SMILES | CCC12C=C(C(=O)OC)n3c4c(c5ccccc53)CCN(CCC1)C42 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| RIDADR | NONH for all modes of transport |
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| Precursor 0 | |
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| DownStream 1 | |
CAS#:42971-09-5|
Effects of aging and vincamine derivatives on pericapillary microenvironment: stereological characterization of the cerebral capillary network.
Neurobiol. Aging 11(1) , 39-46, (1990) Changes in the pericapillary microenvironment of adult (18-month-old) and senescent (27 1/2-month-old) Fischer-344 rats treated for 6 weeks with daily IP injections of brovincamine or apovincamine (0,... |
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Alpneumines A-H, new anti-melanogenic indole alkaloids from Alstonia pneumatophora.
Bioorg. Med. Chem. 18(12) , 4415-21, (2010) Eight new indole alkaloids, alpneumines A-H (1-8) were isolated from the Malaysian Alstonia pneumatophora (Apocynaceae) and their structures were determined by MS and 2D NMR spectroscopic methods. Alp... |
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Synthesis of vinca alkaloids and related compounds. Part 84. Sulfonamide derivatives of some vinca alkaloids with cardiovascular activity.
Arch. Pharm. (Weinheim) 330(6) , 190-8, (1997) (+)-Vincamine (1) and (+)-vinpocetine (2) were chlorosulfonylated and the resulting sulfonyl chloride isomers (3-6) were transformed into sulfonamides (7-10). The ester group of sulfonamides was modif... |
| Apo-14,15-dehydrovincamine |
| 14,15-dehydrovincamine |
| Apovincamina [spanish] |
| eburnamenine-14-carboxylic acid methyl ester |
| Apovincaminum [latin] |
| Apovincaminum |
| Vinpocetine impurity B |
| Apovincaminic acid methyl |
| (3S,16S)-Apovincaminsaeure |
| Apovincamina |
| (+)-trans-Cavinton |