Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Apovincamine
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Purity: 98.0%
Stocking Period: 10 Day
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DC Chemicals Limited
China
Product Name: Apovincamine
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: apovincamine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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4880-92-6

4880-92-6 structure

4880-92-6 structure

Name: Apovincamine
Chemical Name: Apovincamine
CAS Number: 4880-92-6
Molecular Formula: C₂₁H₂₄N₂O₂
Molecular Weight: 336.42700
Catalog: analytical chemistry Standard Pharmacopoeia Standards and Magazine Standards
Create Date: 2018-07-21 16:10:12
Modify Date: 2025-08-20 17:23:52
Apovincamine (cis-Apovincamine) is an indole alkaloid isolated from the Malaysian Alstonia pneumatophora (Apocynaceae). Apovincamine shows anti-melanogenesis activity[1].

Name	Apovincamine
Synonyms	Apo-14,15-dehydrovincamine 14,15-dehydrovincamine Apovincamina [spanish] eburnamenine-14-carboxylic acid methyl ester Apovincaminum [latin] Apovincaminum Vinpocetine impurity B Apovincaminic acid methyl (3S,16S)-Apovincaminsaeure Apovincamina (+)-trans-Cavinton

Description	Apovincamine (cis-Apovincamine) is an indole alkaloid isolated from the Malaysian Alstonia pneumatophora (Apocynaceae). Apovincamine shows anti-melanogenesis activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	Apovincamine (cis-Apovincamine; 6.3, 12.5, 25, 50, 100 μM) dose-dependently inhibits cells viability with an IC50 of 49.8 μM and shows anti-melanogenesis in B16 mouse melanoma cells[1].
References	[1]. Koichiro Koyama, et al. Alpneumines A-H, new anti-melanogenic indole alkaloids from Alstonia pneumatophore. Bioorg Med Chem. 2010 Jun 15;18(12):4415-21.

Density	1.3g/cm3
Boiling Point	405.7ºC at 760mmHg
Melting Point	160-162℃
Molecular Formula	C₂₁H₂₄N₂O₂
Molecular Weight	336.42700
Flash Point	199.1ºC
Exact Mass	336.18400
PSA	34.47000
LogP	3.69610
Index of Refraction	1.678

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JW4793000

CHEMICAL NAME :: Eburnamenine-14-carboxylic acid, methyl ester, (3-alpha,16-alpha)-

CAS REGISTRY NUMBER :: 4880-92-6

LAST UPDATED :: 199806

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C21-H24-N2-O2

MOLECULAR WEIGHT :: 336.47

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRXXBL French Demande Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2319362

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4140777

RIDADR	NONH for all modes of transport

Precursor 0
DownStream 1
42971-09-5

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