Bioorganic & Medicinal Chemistry 2010-06-15

Alpneumines A-H, new anti-melanogenic indole alkaloids from Alstonia pneumatophora.

Koichiro Koyama, Yusuke Hirasawa, Takahiro Hosoya, Teh Chin Hoe, Kit-Lam Chan, Hiroshi Morita

Index: Bioorg. Med. Chem. 18(12) , 4415-21, (2010)

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Abstract

Eight new indole alkaloids, alpneumines A-H (1-8) were isolated from the Malaysian Alstonia pneumatophora (Apocynaceae) and their structures were determined by MS and 2D NMR spectroscopic methods. Alpneumines E and G (5 and 7), vincamine, and apovincamine showed anti-melanogenesis in B16 mouse melanoma cells.Copyright 2010 Elsevier Ltd. All rights reserved.