2,4,6-Trihydroxybenzaldehyde

Modify Date: 2024-01-02 12:41:55

2,4,6-Trihydroxybenzaldehyde Structure
2,4,6-Trihydroxybenzaldehyde structure
Common Name 2,4,6-Trihydroxybenzaldehyde
CAS Number 487-70-7 Molecular Weight 154.120
Density 1.6±0.1 g/cm3 Boiling Point 319.1±22.0 °C at 760 mmHg
Molecular Formula C7H6O4 Melting Point 195 °C (dec.)(lit.)
MSDS USA Flash Point 161.0±18.8 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of 2,4,6-Trihydroxybenzaldehyde


2,4,6-Trihydroxybenzaldehyde is an orally active NF-ĸB inhibitor. 2,4,6-Trihydroxybenzaldehyde shows anti-tumor activity, anti-cancer cell proliferative activity and anti-obesity activity[1][2][3].

 Names

Name 2,4,6-Trihydroxybenzaldehyde
Synonym More Synonyms

 2,4,6-Trihydroxybenzaldehyde Biological Activity

Description 2,4,6-Trihydroxybenzaldehyde is an orally active NF-ĸB inhibitor. 2,4,6-Trihydroxybenzaldehyde shows anti-tumor activity, anti-cancer cell proliferative activity and anti-obesity activity[1][2][3].
Related Catalog
In Vitro 2,4,6-Trihydroxybenzaldehyde inhibits adipocyte differentiation and lipid accumulation in 3T3-L1 cells[1]. 2,4,6-Trihydroxybenzaldehyde down-regulates PPARγ, C/EBPα, SREBP-1c, and FAS protein expression levels[1].
In Vivo 2,4,6-Trihydroxybenzaldehyde (oral administration; 5 and 25 mg/kg for 13 weeks) reduces the HFD-induced increase in weight gain, reduces serum levels of glucose, triglycerides, and total cholesterol[1].

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 319.1±22.0 °C at 760 mmHg
Melting Point 195 °C (dec.)(lit.)
Molecular Formula C7H6O4
Molecular Weight 154.120
Flash Point 161.0±18.8 °C
Exact Mass 154.026611
PSA 77.76000
LogP 1.37
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.734

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CU8440000
CHEMICAL NAME :
Benzaldehyde, 2,4,6-trihydroxy-
CAS REGISTRY NUMBER :
487-70-7
BEILSTEIN REFERENCE NO. :
2254429
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C7-H6-O4
MOLECULAR WEIGHT :
154.13
WISWESSER LINE NOTATION :
VHR BQ DQ FQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3200 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1906- Volume(issue)/page/year: 34,1196,1940

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P280-P305 + P351 + P338-P337 + P313
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS CU8440000
HS Code 2912499000

 Customs

HS Code 2912499000
Summary 2912499000. other aldehyde-ethers, aldehyde-phenols and aldehydes with other oxygen function. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

 Articles3

More Articles
Health-Beneficial Phenolic Aldehyde in Antigonon leptopus Tea.

Evid. Based. Complement. Alternat. Med. 2011 , 601249, (2012)

Tea prepared from the aerial parts of Antigonon leptopus is used as a remedy for cold and pain relief in many countries. In this study, A. leptopus tea, prepared from the dried aerial parts, was evalu...

2,4,6-Trihydroxybenzaldehyde, a potential anti-obesity treatment, suppressed adipocyte differentiation in 3T3-L1 cells and fat accumulation induced by high-fat diet in C57BL/6 mice.

Environ. Toxicol. Pharmacol. 39 , 962-8, (2015)

In the present study, 2,4,6-trihydroxybenzaldehyde (THB) was evaluated for inhibitory effects on adipocyte differentiation in 3T3-L1 cells and anti-obesity effects in mice with high-fat diet (HFD)-ind...

A comprehensive investigation of guaiacyl-pyranoanthocyanin synthesis by one-/two-dimensional NMR and UPLC-DAD-ESI-MS(n).

Food Chem. 199 , 902-10, (2016)

In red and rosé wines, the grape anthocyanins are progressively converted to more stable pigments, including phenylpyranoanthocyanins. One-/two-dimensional NMR and UPLC-DAD-ESI-MS(n) measurements were...

 Synonyms

EINECS 207-663-7
MFCD00003329
Phloroglucinolcarboxaldehyde
Benzaldehyde, 2,4,6-trihydroxy-
2,4,6-Trihydroxybenzaldehyde