Ninhydrin

Modify Date: 2024-01-01 20:43:10

Ninhydrin Structure
Ninhydrin structure
 Common Name Ninhydrin
CAS Number 485-47-2 Molecular Weight 178.141
Density 1.7±0.1 g/cm3 Boiling Point 449.3±45.0 °C at 760 mmHg
Molecular Formula C9H6O4 Melting Point 250 °C (dec.)(lit.)
MSDS Chinese USA Flash Point 239.7±25.2 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Ninhydrin


Ninhydrin can be used as a chromogenic analytical probe for the quantification of amino acids and proteins.

 Names

Name ninhydrin
Synonym More Synonyms

 Ninhydrin Biological Activity

Description Ninhydrin can be used as a chromogenic analytical probe for the quantification of amino acids and proteins.
Related Catalog
Target

IC50: chromogenic analytical probe[1]
In Vitro Ninhydrin is used in amino acid analysis of proteins. Except proline, Most amino acids can be hydrolyzed and react with ninhydrin. The amino acids are then quantified colorimetrically after separation by chromatography. Ninhydrin reacts with primary and secondary amines producing a blue or purple reaction product: diketohydrindylidene-diketohydrindamine.
References

[1]. Omar MA, et al. Utility of ninhydrin reagent for spectrofluorimetric determination of heptaminol in human plasma.Luminescence. 2018 Sep;33(6):1107-1112.

[2]. Anantharaman S, et al. Ninhydrin-sodium molybdate chromogenic analytical probe for the assay of amino acids and proteins.rSpectrochim Acta A Mol Biomol Spectrosc. 2017 Feb 15;173:897-903.

 Chemical & Physical Properties

Density 1.7±0.1 g/cm3
Boiling Point 449.3±45.0 °C at 760 mmHg
Melting Point 250 °C (dec.)(lit.)
Molecular Formula C9H6O4
Molecular Weight 178.141
Flash Point 239.7±25.2 °C
Exact Mass 178.026611
PSA 74.60000
LogP 1.07
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.737
Storage condition Store at RT.
Stability Stable. Incompatible with amines, alkalies, strong bases. Light-sensitive.
Water Solubility 0.1-0.5 g/100 mL at 20 ºC

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NK5425000
CHEMICAL NAME :
1,3-Indandione, 2,2-dihydroxy-
CAS REGISTRY NUMBER :
485-47-2
BEILSTEIN REFERENCE NO. :
1910963
LAST UPDATED :
199701
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C9-H6-O4
MOLECULAR WEIGHT :
178.15
WISWESSER LINE NOTATION :
L56 BV DV CHJ CQ CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,28,1953
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
78 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Vascular - regional or general arteriolar or venous dilation Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849- Volume(issue)/page/year: 151,719,1957 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1175 No. of Facilities: 33 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 594 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1175 No. of Facilities: 476 (estimated) No. of Industries: 4 No. of Occupations: 9 No. of Employees: 5565 (estimated) No. of Female Employees: 4002 (estimated)

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn:Harmful
Risk Phrases R22;R36/37/38
Safety Phrases S26-S28A-S45-S16
RIDADR UN 1170 3/PG 2
WGK Germany 3
RTECS NK5425000
Hazard Class 3.0
HS Code 2915900090

 Synthetic Route

 Customs

HS Code 2915900090
Summary 2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

 Articles85

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 Synonyms

2,2-Dihydroxy-1H-indene-1,3(2H)-dione
Triketohydrinden Hydrate
Ninhydrin
2,2-Dihydroxy-1,3-indanedione
Ninhydrin,spectrophotometric grade
MFCD00003791
Ninhydrin Spray
Ningidrin
indane-1,2,3-trione monohydrate
NyNhydriN
NinhydrinGr
1,2,3-Indanetrione monohydrate
Trioxohydrindene monohydrate
Ninhydrin,ozone friendly ready to use spray
1H-Indene-1,2,3-trione hydrate
Ninhydrin (contains Acetic Acid) Ethanol
1,2,3-Indantrione, 2-hydrate
EINECS 207-618-1
NINHYDRINE
1,2,3-triketohydrindene hydrate
1H-Indene-1,3(2H)-dione, 2,2-dihydroxy-
2,2-dihydroxy-2H-indene-1,3-dione
Ninhydrin hydrate
NinhydrinA.R.
NIN
Ninthydrin
1,3-Indandione, 2,2-dihydroxy-
1,2,3-Indantrione monohydrate
1,2,3-Indantrione monohydrate,2,2-Dihydroxy-1,3-indanedione,Trioxohydrindene monohydrate
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Related Compounds: More...
Reduced Ninhydrin
5103-42-4
benzo[f]ninhydrin
20927-01-9
Ninhydrin-dimethylketal
65299-21-0
Benzo[f]ninhydrin monohydrate
38627-57-5
Chemsrc provides Ninhydrin(CAS#:485-47-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Ninhydrin are included as well.>> amp version: Ninhydrin

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