Byakangelicin

Modify Date: 2025-08-25 21:45:22

Byakangelicin structure	Common Name	Byakangelicin
	CAS Number	482-25-7	Molecular Weight	334.321
	Density	1.4±0.1 g/cm3	Boiling Point	571.5±50.0 °C at 760 mmHg
	Molecular Formula	C₁₇H₁₈O₇	Melting Point	123-124℃
	MSDS	Chinese USA	Flash Point	299.4±30.1 °C
	Symbol	GHS07	Signal Word	Warning

Use of Byakangelicin

Byakangelicin, one of the active compounds found in the roots of Angelica gigas, can serve as a modulator to improve brain accumulation of diverse active compounds (Umb, Cur, and Dox) and enhance therapeutic effects[1]. Byakangelicin is likely to increase the expression of all PXR target genes (such as MDR1) and induce a wide range of drug-drug interactions. Byakangelicin can inhibit the effects of sex hormones, it may increase the catabolism of endogenous hormones[2].

Name	Byakangelicin
Synonym	More Synonyms

Description	Byakangelicin, one of the active compounds found in the roots of Angelica gigas, can serve as a modulator to improve brain accumulation of diverse active compounds (Umb, Cur, and Dox) and enhance therapeutic effects[1]. Byakangelicin is likely to increase the expression of all PXR target genes (such as MDR1) and induce a wide range of drug-drug interactions. Byakangelicin can inhibit the effects of sex hormones, it may increase the catabolism of endogenous hormones[2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
Target	PXR[2]
References	[1]. Kang YY, et al. Byakangelicin as a modulator for improved distribution and bioactivity of natural compounds and synthetic drugs in the brain. Phytomedicine. 2019 May 17;62:152963. [2]. Yang J, et al. Byakangelicin induces cytochrome P450 3A4 expression via transactivation of pregnane X receptors in human hepatocytes. Br J Pharmacol. 2011 Jan;162(2):441-51.

Density	1.4±0.1 g/cm3
Boiling Point	571.5±50.0 °C at 760 mmHg
Melting Point	123-124℃
Molecular Formula	C₁₇H₁₈O₇
Molecular Weight	334.321
Flash Point	299.4±30.1 °C
Exact Mass	334.105255
PSA	102.27000
LogP	1.62
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.613
Storage condition	?20°C

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Hazard Codes	Xn
Risk Phrases	22-36/37/38
Safety Phrases	26
RIDADR	NONH for all modes of transport

Simultaneous determination of byak-angelicin and oxypeucedanin hydrate in rat plasma by column-switching high-performance liquid chromatography with ultraviolet detection.

J. Chromatogr. B. Biomed. Sci. Appl. 753(2) , 309-14, (2001)

A simple and sensitive column-switching HPLC method was developed for the simultaneous determination of two furocoumarin compounds, byak-angelicin and oxypeucedanin hydrate, which are the main compone...

[Studies on quality standards of radix Angelicae dahuricae].

Zhongguo Zhong Yao Za Zhi 29(7) , 654-7, (2004)

To work out a qualitay standard of Radix Angelicae dahuricae.TLC and HPLC were adopted.Four coumerin compounds were identified by TLC, and the contents of two compounds were determined by HPLC.Imperat...

Furocoumarins from Angelica dahurica with hepatoprotective activity on tacrine-induced cytotoxicity in Hep G2 cells.

Planta Med. 68(5) , 463-4, (2002)

Fractionation of the MeOH extract of Angelica dahurica Benth et Hook resulted in the isolation of six furocoumarins, imperatorin (1), isoimperatorin (2), (+/-)-byakangelicol (3), (+)-oxypeucedanin (4)...

7H-Furo[3,2-g][1]benzopyran-7-one, 9-[(2R)-2,3-dihydroxy-3-methylbutoxy]-4-methoxy-

9-[(2R)-2,3-Dihydroxy-3-methylbutoxy]-4-methoxy-7H-furo[3,2-g]chromen-7-one