Byakangelicin

Modify Date: 2024-01-09 20:59:07

Byakangelicin Structure
Byakangelicin structure
Common Name Byakangelicin
CAS Number 482-25-7 Molecular Weight 334.321
Density 1.4±0.1 g/cm3 Boiling Point 571.5±50.0 °C at 760 mmHg
Molecular Formula C17H18O7 Melting Point 123-124℃
MSDS Chinese USA Flash Point 299.4±30.1 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of Byakangelicin


Byakangelicin, one of the active compounds found in the roots of Angelica gigas, can serve as a modulator to improve brain accumulation of diverse active compounds (Umb, Cur, and Dox) and enhance therapeutic effects[1]. Byakangelicin is likely to increase the expression of all PXR target genes (such as MDR1) and induce a wide range of drug-drug interactions. Byakangelicin can inhibit the effects of sex hormones, it may increase the catabolism of endogenous hormones[2].

 Names

Name Byakangelicin
Synonym More Synonyms

 Byakangelicin Biological Activity

Description Byakangelicin, one of the active compounds found in the roots of Angelica gigas, can serve as a modulator to improve brain accumulation of diverse active compounds (Umb, Cur, and Dox) and enhance therapeutic effects[1]. Byakangelicin is likely to increase the expression of all PXR target genes (such as MDR1) and induce a wide range of drug-drug interactions. Byakangelicin can inhibit the effects of sex hormones, it may increase the catabolism of endogenous hormones[2].
Related Catalog
Target

PXR[2]

References

[1]. Kang YY, et al. Byakangelicin as a modulator for improved distribution and bioactivity of natural compounds and synthetic drugs in the brain. Phytomedicine. 2019 May 17;62:152963.

[2]. Yang J, et al. Byakangelicin induces cytochrome P450 3A4 expression via transactivation of pregnane X receptors in human hepatocytes. Br J Pharmacol. 2011 Jan;162(2):441-51.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 571.5±50.0 °C at 760 mmHg
Melting Point 123-124℃
Molecular Formula C17H18O7
Molecular Weight 334.321
Flash Point 299.4±30.1 °C
Exact Mass 334.105255
PSA 102.27000
LogP 1.62
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.613
Storage condition ?20°C

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Hazard Codes Xn
Risk Phrases 22-36/37/38
Safety Phrases 26
RIDADR NONH for all modes of transport

 Articles6

More Articles
Simultaneous determination of byak-angelicin and oxypeucedanin hydrate in rat plasma by column-switching high-performance liquid chromatography with ultraviolet detection.

J. Chromatogr. B. Biomed. Sci. Appl. 753(2) , 309-14, (2001)

A simple and sensitive column-switching HPLC method was developed for the simultaneous determination of two furocoumarin compounds, byak-angelicin and oxypeucedanin hydrate, which are the main compone...

[Studies on quality standards of radix Angelicae dahuricae].

Zhongguo Zhong Yao Za Zhi 29(7) , 654-7, (2004)

To work out a qualitay standard of Radix Angelicae dahuricae.TLC and HPLC were adopted.Four coumerin compounds were identified by TLC, and the contents of two compounds were determined by HPLC.Imperat...

Furocoumarins from Angelica dahurica with hepatoprotective activity on tacrine-induced cytotoxicity in Hep G2 cells.

Planta Med. 68(5) , 463-4, (2002)

Fractionation of the MeOH extract of Angelica dahurica Benth et Hook resulted in the isolation of six furocoumarins, imperatorin (1), isoimperatorin (2), (+/-)-byakangelicol (3), (+)-oxypeucedanin (4)...

 Synonyms

7H-Furo[3,2-g][1]benzopyran-7-one, 9-[(2R)-2,3-dihydroxy-3-methylbutoxy]-4-methoxy-
9-[(2R)-2,3-Dihydroxy-3-methylbutoxy]-4-methoxy-7H-furo[3,2-g]chromen-7-one
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  • China
  • Product Name: Byakangelicin
  • Price: ¥Inquiry/20mg
  • Purity: 98.0%
  • Stocking Period: 1 Day
  • Contact: Xueping-Zheng



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