[Orn8]-Urotensin II acetate
Modify Date: 2025-09-21 18:07:51
![[Orn8]-Urotensin II acetate Structure](https://image.chemsrc.com/caspic/177/479065-85-5.png)
[Orn8]-Urotensin II acetate structure
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Common Name | [Orn8]-Urotensin II acetate | ||
|---|---|---|---|---|
| CAS Number | 479065-85-5 | Molecular Weight | 1434.59 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C65H87N13O20S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of [Orn8]-Urotensin II acetate[Orn8]-Urotensin II acetate is a Urotensin receptor ligand and a partial agonist at Urotensin receptors. |
| Name | [Orn8]-Urotensin II acetate |
|---|
| Description | [Orn8]-Urotensin II acetate is a Urotensin receptor ligand and a partial agonist at Urotensin receptors. |
|---|---|
| In Vivo | [Orn8]-Urotensin II acetate behaves as a full agonist (pEC50 approximately equal 8) at both human and rat UT receptors in the FlipR calcium assay eliciting similar maximal effects as the natural ligand U-II. On the contrary, in the rat aorta bioassay, [Orn8]-Urotensin II acetate behaves as a competitive and selective antagonist (pA2 = 6.56) showing however a small but consistent residual agonist activity[2]. |
| References | 1. Vergura R, et al. Urotensin II stimulates plasma extravasation in mice via UT receptor activation. Naunyn Schmiedebergs Arch Pharmacol. 2004 Nov;370(5):347-52. |
| Molecular Formula | C65H87N13O20S2 |
|---|---|
| Molecular Weight | 1434.59 |
| InChIKey | KBCMJGTVVAXGOV-QXHQCLFZSA-N |
| SMILES | CC(C)C(NC(=O)C1CSSCC(NC(=O)C(CC(=O)O)NC(=O)C2CCCN2C(=O)C(NC(=O)C(N)CCC(=O)O)C(C)O)C(=O)NC(Cc2ccccc2)C(=O)NC(Cc2c[nH]c3ccccc23)C(=O)NC(CCCN)C(=O)NC(Cc2ccc(O)cc2)C(=O)N1)C(=O)O |