[Orn8]-Urotensin II acetate

[Orn8]-Urotensin II acetate is a Urotensin receptor ligand and a partial agonist at Urotensin receptors.

[Orn8]-Urotensin II acetate behaves as a full agonist (pEC50 approximately equal 8) at both human and rat UT receptors in the FlipR calcium assay eliciting similar maximal effects as the natural ligand U-II. On the contrary, in the rat aorta bioassay, [Orn8]-Urotensin II acetate behaves as a competitive and selective antagonist (pA2 = 6.56) showing however a small but consistent residual agonist activity[2].

1. Vergura R, et al. Urotensin II stimulates plasma extravasation in mice via UT receptor activation. Naunyn Schmiedebergs Arch Pharmacol. 2004 Nov;370(5):347-52.