479065-85-5
479065-85-5 structure
- Name: [Orn8]-Urotensin II acetate
- Chemical Name: [Orn8]-Urotensin II acetate
- CAS Number: 479065-85-5
- Molecular Formula: C65H87N13O20S2
- Molecular Weight: 1434.59
- Catalog: Signaling Pathways GPCR/G Protein Urotensin Receptor
- Create Date: 2023-12-26 12:42:33
- Modify Date: 2024-01-12 17:20:19
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[Orn8]-Urotensin II acetate is a Urotensin receptor ligand and a partial agonist at Urotensin receptors.
| Name | [Orn8]-Urotensin II acetate |
|---|
| Description | [Orn8]-Urotensin II acetate is a Urotensin receptor ligand and a partial agonist at Urotensin receptors. |
|---|---|
| In Vivo | [Orn8]-Urotensin II acetate behaves as a full agonist (pEC50 approximately equal 8) at both human and rat UT receptors in the FlipR calcium assay eliciting similar maximal effects as the natural ligand U-II. On the contrary, in the rat aorta bioassay, [Orn8]-Urotensin II acetate behaves as a competitive and selective antagonist (pA2 = 6.56) showing however a small but consistent residual agonist activity[2]. |
| References | 1. Vergura R, et al. Urotensin II stimulates plasma extravasation in mice via UT receptor activation. Naunyn Schmiedebergs Arch Pharmacol. 2004 Nov;370(5):347-52. |
| Molecular Formula | C65H87N13O20S2 |
|---|---|
| Molecular Weight | 1434.59 |