Lucanthone structure
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Common Name | Lucanthone | ||
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CAS Number | 479-50-5 | Molecular Weight | 340.48200 | |
Density | 1.184g/cm3 | Boiling Point | 512.4ºC at 760 mmHg | |
Molecular Formula | C20H24N2OS | Melting Point | 195-196ºC | |
MSDS | N/A | Flash Point | 263.7ºC |
Use of LucanthoneLucanthone is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1). |
Name | lucanthone |
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Synonym | More Synonyms |
Description | Lucanthone is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1). |
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Related Catalog | |
Target |
APE-1[1] |
In Vitro | Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. To investigate the anticancer activity of Lucanthone, cell viability is measured by MTT assay. Lucanthone reduces cell viability to a similar extent in a panel of seven breast cancer cell lines. In addition, a direct comparison reveals that Lucanthone is significantly more potent than Chloroquine (CQ) at reducing breast cancer cell viability with a mean IC50 of 7.2 μM versus 66 μM for CQ. Measurement of cell viability in two representative cell lines (MDA-MB-231 and BT-20) by ATPlite assay and trypan blue exclusion reveals comparable results[2]. |
Cell Assay | Cell viability is assessed by MTT assay. Cells are seeded into 96-well microculture plates at 10,000 cells per well and allowed to attach for 24 h. Cells are then treated with Lucanthone (0, 0.5, 1, 5, 10, 20 and 40 μM), Chloroquine, Vorinostat, or combinations for 72 h. Following drug treatment, MTT is added and cell viability is quantified using a BioTek microplate reader. Effects on cell viability are also determined by measuring ATP levels using the ATPlite assay system and by trypan blue exclusion. Pro-apoptotic effects following in vitro drug exposure are quantified by propidium iodide (PI) staining and fluorescence-activated cell sorting (FACS) analysis of sub-G0/G1 DNA content[2]. |
References |
Density | 1.184g/cm3 |
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Boiling Point | 512.4ºC at 760 mmHg |
Melting Point | 195-196ºC |
Molecular Formula | C20H24N2OS |
Molecular Weight | 340.48200 |
Flash Point | 263.7ºC |
Exact Mass | 340.16100 |
PSA | 60.58000 |
LogP | 4.54980 |
Vapour Pressure | 1.3E-10mmHg at 25°C |
Index of Refraction | 1.638 |
Storage condition | 2-8℃ |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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Precursor 10 | |
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DownStream 0 |
1-(2-Diethylamino-ethylamino)-4-methylthiaxanthon,Lucanthon |
Lycanthone |
thioxanthone |
1-(2-diethylamino-ethylamino)-4-methyl-thioxanthen-9-one |
1-<2-Diaethylamino-aethylamino>-4-methyl-thioxanthenon-(9) |
1-[[2-(Diethylamino)ethyl]amino]-4-methyl-9H-thioxanthen-9-one |
1-(2-Diaethylamino-aethylamino)-4-methyl-thioxanthen-9-on |