Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Lucanthone-d4 hydrochloride
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Purity: 98.0%
Stocking Period: 10 Day
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Email: sales@echemcloud.com

1329613-40-2

1329613-40-2 structure

1329613-40-2 structure

Name: Lucanthone-d4 hydrochloride
Chemical Name: Lucanthone-d4 hydrochloride
CAS Number: 1329613-40-2
Molecular Formula: C₂₀H₂₁D₄ClN₂OS
Molecular Weight: 380.97
Catalog: Signaling Pathways Autophagy Autophagy
Create Date: 2021-10-11 20:26:14
Modify Date: 2024-01-13 20:31:24
Lucanthone-d4 hydrochloride is the deuterium labeled Lucanthone. Lucanthone is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1)[1][2].

Name	Lucanthone-d4 hydrochloride

Description	Lucanthone-d4 hydrochloride is the deuterium labeled Lucanthone. Lucanthone is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1)[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Chowdhury SM, et al. Graphene nanoribbons as a drug delivery agent for lucanthone mediated therapy of glioblastoma multiforme. Nanomedicine. 2015 Jan;11(1):109-18. [3]. Carew JS, et al. Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. J Biol Chem. 2011 Feb 25;286(8):6602-13.

Molecular Formula	C₂₀H₂₁D₄ClN₂OS
Molecular Weight	380.97