d-berbamine

Modify Date: 2025-08-20 10:14:27

d-berbamine Structure
d-berbamine structure
 Common Name d-berbamine
CAS Number 478-61-5 Molecular Weight 608.723
Density 1.2±0.1 g/cm3 Boiling Point 707.0±60.0 °C at 760 mmHg
Molecular Formula C37H40N2O6 Melting Point 225°C
MSDS N/A Flash Point 381.4±32.9 °C

 Use of d-berbamine


Berbamine is a natural compound extracted from traditional Chinese medicine Barberry with anti-tumor, immunomodulatory and cardiovascular effects. Berbamine is a calcium channel blocker.

 Names

Name berbamine
Synonym More Synonyms

 d-berbamine Biological Activity

Description Berbamine is a natural compound extracted from traditional Chinese medicine Barberry with anti-tumor, immunomodulatory and cardiovascular effects. Berbamine is a calcium channel blocker.
Related Catalog
Target

NF-κB

References

[1]. Liang Y, et al. Berbamine, a novel nuclear factor kappaB inhibitor, inhibits growth and induces apoptosis in human myeloma cells. Acta Pharmacol Sin. 2009 Dec;30(12):1659-65.

[2]. Meng Z, et al. Berbamine inhibits the growth of liver cancer cells and cancer-initiating cells by targeting Ca2+/calmodulin-dependent protein kinase II. Mol Cancer Ther. 2013 Oct;12(10):2067-77.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 707.0±60.0 °C at 760 mmHg
Melting Point 225°C
Molecular Formula C37H40N2O6
Molecular Weight 608.723
Flash Point 381.4±32.9 °C
Exact Mass 608.288635
PSA 72.86000
LogP 3.89
Vapour Pressure 0.0±2.3 mmHg at 25°C
Index of Refraction 1.602

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DR9450000
CHEMICAL NAME :
Berbamine
CAS REGISTRY NUMBER :
478-61-5
BEILSTEIN REFERENCE NO. :
0078902
LAST UPDATED :
199709
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C37-H40-N2-O6
MOLECULAR WEIGHT :
608.79
WISWESSER LINE NOTATION :
T-T66 CNT&J C1 HO1 IO- JT66 CNT&J C1 HO1 IO1 B1R DQ COR D1- B-18-J

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,26,1953
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 14,45,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 24,2413,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
17430 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 14,45,1983

 Safety Information

Hazard Codes Xi
Risk Phrases R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases S26-S36

 Synonyms

6,6',7-Trimethoxy-2,2'-dimethylberbaman-12-ol
MFCD00067632
E6 berbamine
BERBAMAN-12-OL,6,6',7-TRIMETHOXY-2,2'-DIMETHYL
6,7,6'-trimethoxy-2,2'-dimethyl-berbaman-12-ol
EINECS 207-523-5
d-berbamine
BERBAINE
Berbaman-12-ol, 6,6',7-trimethoxy-2,2'-dimethyl-
berberamine
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