d-berbamine

Modify Date: 2024-01-02 20:13:45

d-berbamine structure	Common Name	d-berbamine
	CAS Number	478-61-5	Molecular Weight	608.723
	Density	1.2±0.1 g/cm3	Boiling Point	707.0±60.0 °C at 760 mmHg
	Molecular Formula	C₃₇H₄₀N₂O₆	Melting Point	225°C
	MSDS	N/A	Flash Point	381.4±32.9 °C

Use of d-berbamine

Berbamine is a natural compound extracted from traditional Chinese medicine Barberry with anti-tumor, immunomodulatory and cardiovascular effects. Berbamine is a calcium channel blocker.

Name	berbamine
Synonym	More Synonyms

Description	Berbamine is a natural compound extracted from traditional Chinese medicine Barberry with anti-tumor, immunomodulatory and cardiovascular effects. Berbamine is a calcium channel blocker.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy
Target	NF-κB
References	[1]. Liang Y, et al. Berbamine, a novel nuclear factor kappaB inhibitor, inhibits growth and induces apoptosis in human myeloma cells. Acta Pharmacol Sin. 2009 Dec;30(12):1659-65. [2]. Meng Z, et al. Berbamine inhibits the growth of liver cancer cells and cancer-initiating cells by targeting Ca²⁺/calmodulin-dependent protein kinase II. Mol Cancer Ther. 2013 Oct;12(10):2067-77.

Density	1.2±0.1 g/cm3
Boiling Point	707.0±60.0 °C at 760 mmHg
Melting Point	225°C
Molecular Formula	C₃₇H₄₀N₂O₆
Molecular Weight	608.723
Flash Point	381.4±32.9 °C
Exact Mass	608.288635
PSA	72.86000
LogP	3.89
Vapour Pressure	0.0±2.3 mmHg at 25°C
Index of Refraction	1.602

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DR9450000

CHEMICAL NAME :: Berbamine

CAS REGISTRY NUMBER :: 478-61-5

BEILSTEIN REFERENCE NO. :: 0078902

LAST UPDATED :: 199709

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C37-H40-N2-O6

MOLECULAR WEIGHT :: 608.79

WISWESSER LINE NOTATION :: T-T66 CNT&J C1 HO1 IO- JT66 CNT&J C1 HO1 IO1 B1R DQ COR D1- B-18-J

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,26,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 14,45,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 24,2413,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 17430 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 14,45,1983

Hazard Codes	Xi
Risk Phrases	R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases	S26-S36

6,6',7-Trimethoxy-2,2'-dimethylberbaman-12-ol

MFCD00067632

E6 berbamine

BERBAMAN-12-OL,6,6',7-TRIMETHOXY-2,2'-DIMETHYL

6,7,6'-trimethoxy-2,2'-dimethyl-berbaman-12-ol

EINECS 207-523-5

d-berbamine

BERBAINE

Berbaman-12-ol, 6,6',7-trimethoxy-2,2'-dimethyl-

berberamine

BioBioPha
China
Product Name: d-berbamine
Price: ￥Inquiry/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: d-berbamine
Price: ￥2400.0/5mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

Zhejiang Hangyu API Co., Ltd
China
Product Name: BERBAMINE
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

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d-berbamine Biological Activity

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CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

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