Safranin

Modify Date: 2025-08-20 12:57:46

Safranin structure	Common Name	Safranin
	CAS Number	477-73-6	Molecular Weight	350.845
	Density	1.00 g/mL at 20 °C	Boiling Point	N/A
	Molecular Formula	C₂₀H₁₉ClN₄	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	46 °C
	Symbol	GHS05	Signal Word	Danger

Use of Safranin

Safranin (Safranin T) is an important and classical phenazinium dye. Safranin has been extensively used in the academic field as a spectroscopic probe and indicator. Safranin possesses a planar structure and cationic charge. It can readily intercalate into biological macromolecules, including DNA and proteins. Safranin can be used as a redox indicator in the determination of metal ion concentration[1].

Name	3,7-dimethyl-10-phenylphenazin-10-ium-2,8-diamine,chloride
Synonym	More Synonyms

Description	Safranin (Safranin T) is an important and classical phenazinium dye. Safranin has been extensively used in the academic field as a spectroscopic probe and indicator. Safranin possesses a planar structure and cationic charge. It can readily intercalate into biological macromolecules, including DNA and proteins. Safranin can be used as a redox indicator in the determination of metal ion concentration[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Wan H, et al. Structure characterization and optical properties investigation of the four main components of the classical phenazinium dye Safranin O. Analyst. 2019;144(24):7149-7156.

Density	1.00 g/mL at 20 °C
Molecular Formula	C₂₀H₁₉ClN₄
Molecular Weight	350.845
Flash Point	46 °C
Exact Mass	350.129822
PSA	68.81000
LogP	1.61230
Index of Refraction	n20/D 1.339
Stability	Stable.

Safranin MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SG1623000

CHEMICAL NAME :: Phenazinium, 3,7-diamino-2,8-dimethyl-5-phenyl-, chloride

CAS REGISTRY NUMBER :: 477-73-6

LAST UPDATED :: 199701

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C20-H19-N4.Cl

MOLECULAR WEIGHT :: 350.88

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 28740 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 24020 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 26940 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes

MUTATION DATA

TYPE OF TEST :: DNA repair

TEST SYSTEM :: Bacteria - Bacillus subtilis

DOSE/DURATION :: 2 mg/disc

REFERENCE :: TRENAF Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. (Tokyo-toritsu Eisei Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan) V.1- 1949/50- Volume(issue)/page/year: 27,153,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1441 No. of Facilities: 1027 (estimated) No. of Industries: 9 No. of Occupations: 18 No. of Employees: 4314 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1441 No. of Facilities: 1253 (estimated) No. of Industries: 6 No. of Occupations: 10 No. of Employees: 22263 (estimated) No. of Female Employees: 14330 (estimated)

Symbol	GHS05
Signal Word	Danger
Hazard Statements	H318
Precautionary Statements	P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/38
Safety Phrases	26-39-24/25-36-16
RIDADR	UN 1170 3/PG 3
WGK Germany	3
RTECS	SG1623000
HS Code	32041300

o-Toluidine

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Literature: Chemische Berichte, , vol. 28, p. 273 Chemische Berichte, , vol. 16, p. 466 Kuenstliche organische Farbstoffe , S.323. Grundlegende Operationen der Farbenchemie, 3.Aufl. , S.192 DE61692 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 3, p. 794 DE108497 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 5, p. 540 Chemische Berichte, , vol. 13, p. 207 Chemische Berichte, , vol. 16, p. 864 Chemische Berichte, , vol. 5, p. 527 Chemische Berichte, , vol. 12, p. 937,939 Chemische Berichte, , vol. 10, p. 874

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Literature: Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, , vol. 42, p. 945 Chem. Zentralbl., , vol. 81, # II p. 1761

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Precursor 4
CAS#:95-53-4 o-Toluidine CAS#:95-70-5 2,5-Diaminotoluene CAS#:3029-60-5 2,5-Cyclohexadi... CAS#:6406-71-9 4-methyl-N1-phe...
DownStream 1
CAS#:4661-54-5 8-imino-3,7-dim...

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Phenazinium, 3,7-diamino-2,8-dimethyl-5-phenyl-, chloride (1:1)

Safranin T

safranin A

C.I. Basic Red 2 (8CI)

Safranine

safranin Y

3,7-Diamino-2,8-dimethyl-5-phenylphenazin-5-ium chloride

Basic Red 2

Gossypimine

Safranine O,certified

Safranin

EINECS 207-518-8

Hidaco safranine

MFCD00011759

Safranine O

Safranin O

Tolusafranine

Safranine O,high purity biological stain

Cotton Red

Safranin Y or A

Safranine-O chloride

Safranine T

Basic Red 2,Cotton Red,Gossypimine

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Safranin
Price: Check
Purity: 98.0%
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Safranin
Price: ￥288.0/100g ￥98.0/25g
Purity: 98.0%
Delivery: Inquiry
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DC Chemicals Limited
China
Product Name: Safranin
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Basic Red 2
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Basic Red 2
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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