Podophyllotoxinone

Modify Date: 2024-01-12 10:15:18

Podophyllotoxinone Structure
Podophyllotoxinone structure
Common Name Podophyllotoxinone
CAS Number 477-49-6 Molecular Weight 412.38900
Density 1.365 g/cm3 Boiling Point 602.3±55.0℃ at 760 mmHg
Molecular Formula C22H20O8 Melting Point 191.73℃
MSDS N/A Flash Point N/A

 Use of Podophyllotoxinone


Podophyllotoxone is isolated from the roots of Dysosma versipellis and has anti-cancer activities.Podophyllotoxone is able to inhibit the tubulin polymerization[1].

 Names

Name (-)-podophyllotoxon
Synonym More Synonyms

 Podophyllotoxinone Biological Activity

Description Podophyllotoxone is isolated from the roots of Dysosma versipellis and has anti-cancer activities.Podophyllotoxone is able to inhibit the tubulin polymerization[1].
Related Catalog
Target

Microtubule/Tubulin[1]

In Vitro Podophyllotoxone inhibits human prostate cancer cells PC3 and DU145 growth with IC50 values of 14.7 and 20.6 µM[1].
References

[1]. Juan Li , et al. Absolute Configuration of Podophyllotoxone and Its Inhibitory Activity Against Human Prostate Cancer Cells. Chin J Nat Med. 2015 Jan;13(1):59-64.

 Chemical & Physical Properties

Density 1.365 g/cm3
Boiling Point 602.3±55.0℃ at 760 mmHg
Melting Point 191.73℃
Molecular Formula C22H20O8
Molecular Weight 412.38900
Exact Mass 412.11600
PSA 89.52000
LogP 2.55850
Vapour Pressure 1.83E-14mmHg at 25°C

 Precursor & DownStream

Precursor  0

DownStream  1

 Synonyms

Podophyllotoxone
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