Podophyllotoxinone

Names

[ CAS No. ]:
477-49-6

[ Name ]:
Podophyllotoxinone

[Synonym ]:
Podophyllotoxone

Biological Activity

[Description]:

Podophyllotoxone is isolated from the roots of Dysosma versipellis and has anti-cancer activities.Podophyllotoxone is able to inhibit the tubulin polymerization[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin

Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[Target]

Microtubule/Tubulin[1]

[In Vitro]

Podophyllotoxone inhibits human prostate cancer cells PC3 and DU145 growth with IC50 values of 14.7 and 20.6 µM[1].

[References]

[1]. Juan Li , et al. Absolute Configuration of Podophyllotoxone and Its Inhibitory Activity Against Human Prostate Cancer Cells. Chin J Nat Med. 2015 Jan;13(1):59-64.

Chemical & Physical Properties

[ Density]:
1.365 g/cm3

[ Boiling Point ]:
602.3±55.0℃ at 760 mmHg

[ Melting Point ]:
191.73℃

[ Molecular Formula ]:
C₂₂H₂₀O₈

[ Molecular Weight ]:
412.38900

[ Exact Mass ]:
412.11600

[ PSA ]:
89.52000

[ LogP ]:
2.55850

[ Vapour Pressure ]:
1.83E-14mmHg at 25°C

Precursor & DownStream

Precursor

DownStream

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.