MRE-269

Modify Date: 2024-01-05 10:14:27

MRE-269 structure	Common Name	MRE-269
	CAS Number	475085-57-5	Molecular Weight	419.516
	Density	1.2±0.1 g/cm3	Boiling Point	602.1±55.0 °C at 760 mmHg
	Molecular Formula	C₂₅H₂₉N₃O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	318.0±31.5 °C

Use of MRE-269

MRE-269 is an active metabolite of selexipag, and acts as a selective IP receptor agonist.

Name	{4-[(5,6-Diphenyl-2-pyrazinyl)(isopropyl)amino]butoxy}acetic acid
Synonym	More Synonyms

Description	MRE-269 is an active metabolite of selexipag, and acts as a selective IP receptor agonist.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor Research Areas >> Cardiovascular Disease
Target	IP Receptor
In Vitro	MRE-269 induces endothelium-independent vasodilation of rat extralobar pulmonary artery (EPA). MRE-269 or other IP receptor agonists including epoprostenol, iloprost, treprostinil and beraprost increase cAMP levels in hPASMC[1]. MRE-269 induces concentration-dependent vasodilation in LPA(+), LPA(-), and SPA(-)[3].
In Vivo	The vasorelaxant effects of MRE-269 on rat small intralobar pulmonary artery (SIPA) and EPA are the same, while the other IP receptor agonists induce less vasodilation in SIPA than in EPA[1]. MRE-269 produces substantial relaxation of rat small pulmonary artery, although its effects are only significant at high concentrations of above 10 μM (pEC50, 4.98±0.22). By contrast, in rat small pulmonary veins, MRE-269 only produces minimal relaxation over the whole concentration range, with only significant relaxation occurring at the two highest doses of MRE-269 of 10 and 100 μM[2].
References	[1]. Fuchikami C, et al. A comparison of vasodilation mode among selexipag (NS-304; [2-{4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide]), its active metabolite MRE-269 and various prostacyclin receptor agonists in rat, porcin [2]. Orie NN, et al. Differential actions of the prostacyclin analogues treprostinil and iloprost and the selexipag metabolite, MRE-269 (ACT-333679) in rat small pulmonary arteries and veins. Prostaglandins Other Lipid Mediat. 2013 Oct;106:1-7 [3]. Kuwano K, et al. A long-acting and highly selective prostacyclin receptor agonist prodrug, 2-{4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), ameliorates rat pulmonary hypertension with unique relaxant responses

Density	1.2±0.1 g/cm3
Boiling Point	602.1±55.0 °C at 760 mmHg
Molecular Formula	C₂₅H₂₉N₃O₃
Molecular Weight	419.516
Flash Point	318.0±31.5 °C
Exact Mass	419.220886
PSA	75.55000
LogP	5.09
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.588
Storage condition	2-8℃

2-{4-[N-(5,6-di...

CAS#:475084-96-9

MRE-269

CAS#:475085-57-5

Literature: Asaki, Tetsuo; Hamamoto, Taisuke; Sugiyama, Yukiteru; Kuwano, Keiichi; Kuwabara, Kenji Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 21 p. 6692 - 6704

Precursor 1
CAS#:475084-96-9 2-{4-[N-(5,6-di...
DownStream 0

Acetic acid, 2-[4-[(5,6-diphenyl-2-pyrazinyl)(1-methylethyl)amino]butoxy]-

MRE-269

2-[4-({[(3,5-DICHLOROPHENYL)AMINO]CARBONYL}AMINO)PHENOXY]-2-METHYLPROPANOIC ACID

2-(4-{[(3,5-dichlorophenyl)carbamoyl]amino}phenoxy)-2-methylpropanoic acid

{4-[(5,6-diphenylpyrazin-2-yl)(propan-2-yl)amino]butoxy}acetic acid

{4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}acetic acid

4-(3,5-dichlorophenylureido)phenoxyisobutyric acid

{4-[(5,6-Diphenyl-2-pyrazinyl)(isopropyl)amino]butoxy}acetic acid

ACT-333679

2-<4<<<(3,5-dichlorophenyl)amino>carbonyl>amino>phenoxy>-2-methylpropionic acid

2-{4-[N'-(3,5-dichlorophenyl)ureido]phenoxy}isobutyric acid

2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}acetic acid

Propanoic acid,2-[4-[[[(3,5-dichlorophenyl)amino]carbonyl]amino]phenoxy]-2-methyl

DC Chemicals Limited
China
Product Name: MRE-269
Price: $500.0/100mg $800.0/250mg $1600.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: [4-[(5,6-diphenylpyrazinyl)(1-methylethyl)amino]butoxy]-acetic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: [4-[(5,6-DIPHENYLPYRAZINYL)(1-METHYLETHYL)AMINO]BUTOXY]-ACETIC ACID
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Price: $177/10mM*1mLinDMSO

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MRE-269

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