Peucedanol
Modify Date: 2024-01-24 22:25:10
Peucedanol structure
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Common Name | Peucedanol | ||
|---|---|---|---|---|
| CAS Number | 46992-81-8 | Molecular Weight | 264.274 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 531.6±50.0 °C at 760 mmHg | |
| Molecular Formula | C14H16O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 204.8±23.6 °C | |
Use of PeucedanolPeucedanol is a non-competitive inhibitor of CYP3A4 with a Ki value of 4.07 μM and a competitive inhibitor of CYP1A2 and CYP2D6 with Ki values of 3.39 μM and 6.77 μM, respectively[1]. |
| Name | 6-(2,3-dihydroxy-3-methylbutyl)-7-hydroxychromen-2-one |
|---|---|
| Synonym | More Synonyms |
| Description | Peucedanol is a non-competitive inhibitor of CYP3A4 with a Ki value of 4.07 μM and a competitive inhibitor of CYP1A2 and CYP2D6 with Ki values of 3.39 μM and 6.77 μM, respectively[1]. |
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| Related Catalog | |
| In Vitro | Peucedanol (0、2.5、5、10、25、50 和 100 μM；0-30 分钟) 与八种人肝脏 CYP 亚型 (CYP1A2、2A6、3A4、2C8、2C9、2C19、2D6 和 2E1) 一起孵育， 在合并的人肝微粒体 (HLM) 中作用 30 分钟，特异性抑制剂作为阳性对照。Peucedanol 以剂量依赖性方式显着抑制 CYP1A2、2D6 和 3A4 的活性，IC50 值分别为 6.03 μM 、13.57 μM 和 7.58 μM[1]。 |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 531.6±50.0 °C at 760 mmHg |
| Molecular Formula | C14H16O5 |
| Molecular Weight | 264.274 |
| Flash Point | 204.8±23.6 °C |
| Exact Mass | 264.099762 |
| PSA | 90.90000 |
| LogP | 0.41 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.622 |
| 2H-1-Benzopyran-2-one, 6-(2,3-dihydroxy-3-methylbutyl)-7-hydroxy- |
| 6-(2,3-Dihydroxy-3-methylbutyl)-7-hydroxy-2H-chromen-2-one |
| Coumarin, 6-(2,3-dihydroxy-3-methylbutyl)-7-hydroxy- |