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Peucedanol

Names

[ CAS No. ]:
46992-81-8

[ Name ]:
Peucedanol

[Synonym ]:
2H-1-Benzopyran-2-one, 6-(2,3-dihydroxy-3-methylbutyl)-7-hydroxy-
6-(2,3-Dihydroxy-3-methylbutyl)-7-hydroxy-2H-chromen-2-one
Coumarin, 6-(2,3-dihydroxy-3-methylbutyl)-7-hydroxy-

Biological Activity

[Description]:

Peucedanol is a non-competitive inhibitor of CYP3A4 with a Ki value of 4.07 μM and a competitive inhibitor of CYP1A2 and CYP2D6 with Ki values of 3.39 μM and 6.77 μM, respectively[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450
Research Areas >> Metabolic Disease

[In Vitro]

Peucedanol (0、2.5、5、10、25、50 和 100 μM；0-30 分钟) 与八种人肝脏 CYP 亚型 (CYP1A2、2A6、3A4、2C8、2C9、2C19、2D6 和 2E1) 一起孵育， 在合并的人肝微粒体 (HLM) 中作用 30 分钟，特异性抑制剂作为阳性对照。Peucedanol 以剂量依赖性方式显着抑制 CYP1A2、2D6 和 3A4 的活性，IC50 值分别为 6.03 μM 、13.57 μM 和 7.58 μM[1]。

[References]

[1]. Cun Zhang, et al. In vitro study on the effect of peucedanol on the activity of cytochrome P450 enzymes. Pharm Biol. 2021 Dec;59(1):935-940.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
531.6±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C14H16O5

[ Molecular Weight ]:
264.274

[ Flash Point ]:
204.8±23.6 °C

[ Exact Mass ]:
264.099762

[ PSA ]:
90.90000

[ LogP ]:
0.41

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.622

Related Compounds