46992-81-8

46992-81-8 structure

Name: Peucedanol
Chemical Name: 6-(2,3-dihydroxy-3-methylbutyl)-7-hydroxychromen-2-one
CAS Number: 46992-81-8
Molecular Formula: C₁₄H₁₆O₅
Molecular Weight: 264.274
Catalog: Signaling Pathways Metabolic Enzyme/Protease Cytochrome P450
Create Date: 2016-07-01 11:45:23
Modify Date: 2024-01-24 22:25:10
Peucedanol is a non-competitive inhibitor of CYP3A4 with a Ki value of 4.07 μM and a competitive inhibitor of CYP1A2 and CYP2D6 with Ki values of 3.39 μM and 6.77 μM, respectively[1].

Name	6-(2,3-dihydroxy-3-methylbutyl)-7-hydroxychromen-2-one
Synonyms	2H-1-Benzopyran-2-one, 6-(2,3-dihydroxy-3-methylbutyl)-7-hydroxy- 6-(2,3-Dihydroxy-3-methylbutyl)-7-hydroxy-2H-chromen-2-one Coumarin, 6-(2,3-dihydroxy-3-methylbutyl)-7-hydroxy-

Description	Peucedanol is a non-competitive inhibitor of CYP3A4 with a Ki value of 4.07 μM and a competitive inhibitor of CYP1A2 and CYP2D6 with Ki values of 3.39 μM and 6.77 μM, respectively[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Research Areas >> Metabolic Disease
In Vitro	Peucedanol (0、2.5、5、10、25、50 和 100 μM；0-30 分钟) 与八种人肝脏 CYP 亚型 (CYP1A2、2A6、3A4、2C8、2C9、2C19、2D6 和 2E1) 一起孵育，在合并的人肝微粒体 (HLM) 中作用 30 分钟，特异性抑制剂作为阳性对照。Peucedanol 以剂量依赖性方式显着抑制 CYP1A2、2D6 和 3A4 的活性，IC50 值分别为 6.03 μM 、13.57 μM 和 7.58 μM[1]。
References	[1]. Cun Zhang, et al. In vitro study on the effect of peucedanol on the activity of cytochrome P450 enzymes. Pharm Biol. 2021 Dec;59(1):935-940.