Thiomandelic acid

Modify Date: 2024-01-21 15:10:25

Thiomandelic acid Structure
Thiomandelic acid structure
 Common Name Thiomandelic acid
CAS Number 4695-09-4 Molecular Weight 168.21300
Density N/A Boiling Point N/A
Molecular Formula C8H8O2S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Thiomandelic acid


Thiomandelic acid is a broad spectrum inhibitor of Zinc -lactamases[1].

 Names

Name 2-phenyl-2-sulfanylacetic acid
Synonym More Synonyms

 Thiomandelic acid Biological Activity

Description Thiomandelic acid is a broad spectrum inhibitor of Zinc -lactamases[1].
Related Catalog
In Vitro Thiomandelic acid is found to be a reasonably potent (submicromolar) inhibitor for all of the MBLs tested, except for the subclass B2 enzyme from A. hydrophila (CphA)[1]. Thiomandelic Acid binds to both metal ions in metallo-β-lactamase and induces positive cooperativity in metal binding[2].
References

[1]. C Mollard, et al. Thiomandelic acid, a broad spectrum inhibitor of zinc beta-lactamases: kinetic and spectroscopic studies. J Biol Chem. 2001 Nov 30;276(48):45015-23.

[2]. Christian Damblon, et al. The inhibitor thiomandelic acid binds to both metal ions in metallo-beta-lactamase and induces positive cooperativity in metal binding. J Biol Chem. 2003 Aug 1;278(31):29240-51.

 Chemical & Physical Properties

Molecular Formula C8H8O2S
Molecular Weight 168.21300
Exact Mass 168.02500
PSA 76.10000
LogP 1.74210

 Safety Information

Hazard Codes Xi

 Synthetic Route

S-acetyl-α-phenyl-α-mercaptoacetic acid structure

S-acetyl-α-phen...

CAS#:41128-19-2

~88%

Thiomandelic acid Structure

Thiomandelic acid

CAS#:4695-09-4

Literature: THE UNIVERSITY OF EDINBURGH; WEBSTER, Scott, Peter; SECKL, Jonathan, Robert; WALKER, Brian, Robert; WARD, Peter; PALLIN, Thomas, David; DYKE, Hazel, Joan; PERRIOR, Trevor, Robert Patent: WO2010/146338 A1, 2010 ; Location in patent: Page/Page column 77 ; WO 2010/146338 A1
2-Bromo-2-phenylacetic acid structure

2-Bromo-2-pheny...

CAS#:4870-65-9

~68%

Thiomandelic acid Structure

Thiomandelic acid

CAS#:4695-09-4

Literature: Kudelko, Agnieszka Tetrahedron, 2012 , vol. 68, # 18 p. 3616 - 3625
2-amino-5-phenyl-1,3-thiazol-4-one structure

2-amino-5-pheny...

CAS#:1762-68-1

~68%

Thiomandelic acid Structure

Thiomandelic acid

CAS#:4695-09-4

Literature: A. H. Robins Company, Inc. Patent: US5061720 A1, 1991 ; US 5061720 A
Mandelic acid structure

Mandelic acid

CAS#:611-71-2

~%

Thiomandelic acid Structure

Thiomandelic acid

CAS#:4695-09-4

Literature: Lu, Dongning; Nadas, Janos; Zhang, Guisheng; Johnson, Wesley; Zweier, Jay L.; Cardounel, Arturo J.; Villamena, Frederick A.; Wang, Peng George Journal of the American Chemical Society, 2007 , vol. 129, # 17 p. 5503 - 5514
Benzeneacetic acid, α-chloro- structure

Benzeneacetic a...

CAS#:4755-72-0

~%

Thiomandelic acid Structure

Thiomandelic acid

CAS#:4695-09-4

Literature: Parravano; Tommasi Gazzetta Chimica Italiana, 1909 , vol. 39 II, p. 62
(+/-)-ethoxythiocarbonylmercapto-phenyl-acetic acid structure

(+/-)-ethoxythi...

CAS#:56601-83-3

~%

Thiomandelic acid Structure

Thiomandelic acid

CAS#:4695-09-4

Literature: McIntosh, John M.; Siddiqui, Maqbool A. Canadian Journal of Chemistry, 1983 , vol. 61, p. 1872 - 1875
4-nitrosotoluene structure

4-nitrosotoluene

CAS#:623-11-0

N/A structure

N/A

CAS#:4695-07-2

~%

Phenylglyoxylic acid structure

Phenylglyoxylic acid

CAS#:611-73-4

Thiomandelic acid Structure

Thiomandelic acid

CAS#:4695-09-4

Literature: Schoeberl; Berninger; Harren Chemische Berichte, 1934 , vol. 67, p. 1545,1550 Full Text Show Details Schoeberl; Eck Justus Liebigs Annalen der Chemie, 1936 , vol. 522, p. 97,107

 Synonyms

Thiomandelic acid
rac-Thiomandelsaeure
phenylmercaptoacetic acid
Top Suppliers:I want be here

Get all suppliers and price by the below link:

Thiomandelic acid suppliers

Thiomandelic acid price

Related Compounds: More...
Thiovaleric acid S-sec-butyl ester
2450-11-5
Octanethioic acid S-propyl ester
2432-85-1
Hexanethioic acid S-decyl ester
2432-81-7
Thiopropionic acid S-undecyl ester
2432-46-4
trisporic acid
11043-91-7
Benzoic acid, 3,4-dihydroxy-, 2-Methylpropyl ester
105603-54-1
Benzenesulfonic acid, 3,3-methylenebis2,4(or 4,6)-dihydroxyphenyleneazobis-, potassium sodium salt
243869-48-9
Benzoic acid, 3,4-dihydroxy-, 1-Methylpropyl ester
105622-98-8
butanedioic acid,sodium
14047-56-4
N-(2-ethoxyphenyl)-2-((3-(4-methoxyphenyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)thio)acetamide
863500-42-9
N-(3,4-dimethoxyphenyl)-2-((3-(4-methoxyphenyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)thio)acetamide
863500-46-3
N-(benzo[d][1,3]dioxol-5-yl)-2-((3-(4-methoxyphenyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)thio)acetamide
863500-47-4
2-((3-(4-methoxyphenyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)thio)-N-(4-(trifluoromethyl)phenyl)acetamide
863500-51-0
N-(4-acetamidophenyl)-2-((3-(4-methoxyphenyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)thio)acetamide
863500-58-7
(2Z)-3-(furan-2-yl)-2-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]prop-2-enenitrile
476675-00-0
(2Z)-3-(furan-2-yl)-2-[4-(3-methoxyphenyl)-1,3-thiazol-2-yl]prop-2-enenitrile
476675-06-6
Diethyl 5,5'-((2,2'-oxybis(acetyl))bis(azanediyl))bis(3-methylthiophene-2-carboxylate)
477571-92-9
(3,5-di(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)(3-methoxyphenyl)methanone
865615-88-9
3-(1-(2-((2-(cyclohex-1-en-1-yl)ethyl)amino)-2-oxoethyl)-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-N-cyclopentylpropanamide
865655-12-5
Chemsrc provides Thiomandelic acid(CAS#:4695-09-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Thiomandelic acid are included as well.>> amp version: Thiomandelic acid

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved