CYCLOARTENOL

Modify Date: 2024-01-02 17:00:19

CYCLOARTENOL structure	Common Name	CYCLOARTENOL
	CAS Number	469-38-5	Molecular Weight	426.71700
	Density	1.01 g/cm3	Boiling Point	505.5ºC at 760 mmHg
	Molecular Formula	C₃₀H₅₀O	Melting Point	115-117ºC
	MSDS	N/A	Flash Point	221.9ºC

Use of CYCLOARTENOL

Cycloartenol, a phytosterol compound, is one of the key precusor substances for biosynthesis of numerous sterol compounds. Cycloartenol inhibits the migration of glioma cells and suppresses the phosphorylation of the p38 MAP kinase. Cycloartenol has a variety of pharmacological activities such as anti-inflammatory, anti-tumor, antioxidant, antibiosis and anti-alzheimer's disease. Cycloartenol also plays an important role in the process of plant growth and development[1][2].

Name	cycloartenol
Synonym	More Synonyms

Description	Cycloartenol, a phytosterol compound, is one of the key precusor substances for biosynthesis of numerous sterol compounds. Cycloartenol inhibits the migration of glioma cells and suppresses the phosphorylation of the p38 MAP kinase. Cycloartenol has a variety of pharmacological activities such as anti-inflammatory, anti-tumor, antioxidant, antibiosis and anti-alzheimer's disease. Cycloartenol also plays an important role in the process of plant growth and development[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK
In Vitro	Cycloartenol inhibits the proliferation and the colony formation potential of the glioma U87 cells in a concentration-dependent manner. The antiproliferative effects are found to be due to induction of Sub-G1 cell cycle arrest and triggering of apoptosis. Cycloartenol also causes significant alteration in the expression of Bax and Bcl-2[2].
References	[1]. Niu H, et al. Cycloartenol exerts anti-proliferative effects on Glioma U87 cells via induction of cell cycle arrest and p38 MAPK-mediated apoptosis. J BUON. 2018 Nov-Dec;23(6):1840-1845. [2]. Zhang ZL, et al. [Research advance of functional plant pharmaceutical cycloartenol about pharmacological and physiological activity]. Zhongguo Zhong Yao Za Zhi. 2017 Feb;42(3):433-437.

Density	1.01 g/cm3
Boiling Point	505.5ºC at 760 mmHg
Melting Point	115-117ºC
Molecular Formula	C₃₀H₅₀O
Molecular Weight	426.71700
Flash Point	221.9ºC
Exact Mass	426.38600
PSA	20.23000
LogP	8.16890
Vapour Pressure	2.47E-12mmHg at 25°C
Index of Refraction	1.538

CYCLOARTENOL MSDS(Chinese)

Hazard Codes	Xi: Irritant;
Safety Phrases	22-24/25

Methanol

CAS#:67-56-1

Cycloartenyl fe...

CAS#:21238-33-5

24-methylenecyc...

CAS#:1449-09-8

CYCLOARTENOL

CAS#:469-38-5

Literature: MORINAGA MILK INDUSTRY CO., LTD. Patent: EP1882472 A1, 2008 ; Location in patent: Page/Page column 14 ;

Cycloartenyl fe...

CAS#:21238-33-5

~93%

CYCLOARTENOL

CAS#:469-38-5

Literature: Yoshida, Kumi; Hirose, Yoshihiko; Imai, Yutaka; Kondo, Tadao Agricultural and Biological Chemistry, 1989 , vol. 53, # 7 p. 1901 - 1912

2,3-Oxidosqualene

CAS#:14050-42-1

Parkeol

CAS#:514-45-4

CYCLOARTENOL

CAS#:469-38-5

Lanosterin

CAS#:79-63-0

Literature: Hart, Elizabeth A.; Hua, Ling; Darr, Lisa B.; Wilson, William K.; Pang, Jihai; Matsuda, Seiichi P. T. Journal of the American Chemical Society, 1999 , vol. 121, # 42 p. 9887 - 9888

3(S)-Oxidosqualene

CAS#:54910-48-4

Parkeol

CAS#:514-45-4

CYCLOARTENOL

CAS#:469-38-5

Lanosterin

CAS#:79-63-0

Literature: Lodeiro, Silvia; Schulz-Gasch, Tanja; Matsuda, Seiichi P. T. Journal of the American Chemical Society, 2005 , vol. 127, # 41 p. 14132 - 14133

Cycloartenol acetate

CAS#:1259-10-5

CYCLOARTENOL

CAS#:469-38-5

Literature: Seo, Shujiro; Uomori, Atsuko; Yoshimura, Yohko; Takeda, Ken'ichi; Seto, Haruo; et.al. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 2407 - 2414

2,3-Oxidosqualene

CAS#:14050-42-1

CYCLOARTENOL

CAS#:469-38-5

Literature: Matsuda; Darr; Hart; Herrera; McCann; Meyer; Pang; Schepmann Organic letters, 2000 , vol. 2, # 15 p. 2261 - 2263

Arundinol

CAS#:136891-87-7

CYCLOARTENOL

CAS#:469-38-5

Literature: Majumder; Ghosal Journal of the Indian Chemical Society, 1991 , vol. 68, # 2 p. 88 - 91

Precursor 5
CAS#:67-56-1 Methanol CAS#:21238-33-5 Cycloartenyl fe... CAS#:14050-42-1 2,3-Oxidosqualene CAS#:1259-10-5 Cycloartenol acetate
CAS#:136891-87-7 Arundinol
DownStream 6
CAS#:21238-33-5 Cycloartenyl fe... CAS#:514-45-4 Parkeol CAS#:79-63-0 Lanosterin CAS#:110654-88-1 Cucurbita-5(10)...
CAS#:23515-91-5 (5α)-eupha-7,24... CAS#:35012-08-9 Cucurbitadienol