Thalifendine chloride

Modify Date: 2025-08-27 13:55:47

Thalifendine chloride structure	Common Name	Thalifendine chloride
	CAS Number	4668-19-3	Molecular Weight	357.79
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₁₆ClNO₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Thalifendine chloride

Thalifendine chloride is a metabolite of Berberine (HY-N0716), with antiplasmodial and antiamoebic activities. Thalifendine chloride shows activity against P. falciparum and E. histolytica with IC50s of 7.91 μM and 116 μM, respectively[1][2].

Name	Thalifendine chloride

Description	Thalifendine chloride is a metabolite of Berberine (HY-N0716), with antiplasmodial and antiamoebic activities. Thalifendine chloride shows activity against P. falciparum and E. histolytica with IC50s of 7.91 μM and 116 μM, respectively[1][2].
Related Catalog	Research Areas >> Infection
Target	IC50: 7.91μM (P. falciparum), 116 μM (E. histolytica)[2]
References	[1]. Yi Li, et al. Bioactivities of berberine metabolites after transformation through CYP450 isoenzymes. J Transl Med. 2011; 9: 62. [2]. C W Wright, et al. In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids. J Nat Prod. 2000 Dec;63(12):1638-40. [3]. Ashish Kumar, et al. A new bisbenzylisoquinoline alkaloid isolated from Thalictrum foliolosum, as a potent inhibitor of DNA topoisomerase IB of Leishmania donovani. Fitoterapia. 2016 Mar;109:25-30.

Molecular Formula	C₁₉H₁₆ClNO₄
Molecular Weight	357.79

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Thalifendine chloride

Use of Thalifendine chloride

Names

Thalifendine chloride Biological Activity

Chemical & Physical Properties

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