4668-19-3

4668-19-3 structure

Name: Thalifendine chloride
Chemical Name: Thalifendine chloride
CAS Number: 4668-19-3
Molecular Formula: C₁₉H₁₆ClNO₄
Molecular Weight: 357.79
Catalog: Research Areas Infection
Create Date: 2021-01-11 21:37:35
Modify Date: 2025-08-27 13:55:47
Thalifendine chloride is a metabolite of Berberine (HY-N0716), with antiplasmodial and antiamoebic activities. Thalifendine chloride shows activity against P. falciparum and E. histolytica with IC50s of 7.91 μM and 116 μM, respectively[1][2].

Name	Thalifendine chloride

Description	Thalifendine chloride is a metabolite of Berberine (HY-N0716), with antiplasmodial and antiamoebic activities. Thalifendine chloride shows activity against P. falciparum and E. histolytica with IC50s of 7.91 μM and 116 μM, respectively[1][2].
Related Catalog	Research Areas >> Infection
Target	IC50: 7.91μM (P. falciparum), 116 μM (E. histolytica)[2]
References	[1]. Yi Li, et al. Bioactivities of berberine metabolites after transformation through CYP450 isoenzymes. J Transl Med. 2011; 9: 62. [2]. C W Wright, et al. In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids. J Nat Prod. 2000 Dec;63(12):1638-40. [3]. Ashish Kumar, et al. A new bisbenzylisoquinoline alkaloid isolated from Thalictrum foliolosum, as a potent inhibitor of DNA topoisomerase IB of Leishmania donovani. Fitoterapia. 2016 Mar;109:25-30.

Molecular Formula	C₁₉H₁₆ClNO₄
Molecular Weight	357.79