Thalifendine chloride

Names

[ Name ]:
Thalifendine chloride

Biological Activity

[Description]:

Thalifendine chloride is a metabolite of Berberine (HY-N0716), with antiplasmodial and antiamoebic activities. Thalifendine chloride shows activity against P. falciparum and E. histolytica with IC50s of 7.91 μM and 116 μM, respectively[1][2].

[Related Catalog]:

Research Areas >> Infection

[Target]

IC50: 7.91μM (P. falciparum), 116 μM (E. histolytica)[2]

[References]

[1]. Yi Li, et al. Bioactivities of berberine metabolites after transformation through CYP450 isoenzymes. J Transl Med. 2011; 9: 62.

[2]. C W Wright, et al. In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids. J Nat Prod. 2000 Dec;63(12):1638-40.

[3]. Ashish Kumar, et al. A new bisbenzylisoquinoline alkaloid isolated from Thalictrum foliolosum, as a potent inhibitor of DNA topoisomerase IB of Leishmania donovani. Fitoterapia. 2016 Mar;109:25-30.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₁₆ClNO₄

[ Molecular Weight ]:
357.79

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.