Topoisomerase II inhibitor 13
Modify Date: 2025-09-07 18:59:27
Topoisomerase II inhibitor 13 structure
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Common Name | Topoisomerase II inhibitor 13 | ||
|---|---|---|---|---|
| CAS Number | 451515-89-2 | Molecular Weight | 413.48 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 715.0±70.0 °C at 760 mmHg | |
| Molecular Formula | C22H23N9 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 386.2±35.7 °C | |
Use of Topoisomerase II inhibitor 13Topoisomerase II inhibitor 13 is a topoisomerase II (Topo II) inhibitor. Topoisomerase II inhibitor 13 shows antiproliferative activity against several cancer cells. Topoisomerase II inhibitor 13 induces cancer cells apoptosis[1]. |
| Name | WAY-323966 |
|---|---|
| Synonym | More Synonyms |
| Description | Topoisomerase II inhibitor 13 is a topoisomerase II (Topo II) inhibitor. Topoisomerase II inhibitor 13 shows antiproliferative activity against several cancer cells. Topoisomerase II inhibitor 13 induces cancer cells apoptosis[1]. |
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| Related Catalog | |
| Target |
Topoisomerase II |
| In Vitro | Topoisomerase II inhibitor 13 (compound 3m) (20 μM，50 μM) 在 20 μM 时发挥强烈的抑制作用，几乎完全抑制 Topo II 活性[1]。 Topoisomerase II inhibitor 13 抑制癌细胞增殖，IC50 分别为 25.85 μM (MDA-MB-231)、1.82 μM (A549)、10.38 μM (K562)、1.73 μM (Raji)、1.23 μM (HL-60) 和 0.87 μM (HL-60/MX2)[1]。 |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 715.0±70.0 °C at 760 mmHg |
| Molecular Formula | C22H23N9 |
| Molecular Weight | 413.48 |
| Flash Point | 386.2±35.7 °C |
| Exact Mass | 413.207642 |
| LogP | 3.27 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Index of Refraction | 1.721 |
| InChIKey | SZUYNNSSCOCFTF-UHFFFAOYSA-N |
| SMILES | CCN(CC)CCCn1c(N)c(-c2nc3ccccc3[nH]2)c2nc(C#N)c(C#N)nc21 |
| 6-Amino-7-(1H-benzimidazol-2-yl)-5-[3-(diethylamino)propyl]-5H-pyrrolo[2,3-b]pyrazine-2,3-dicarbonitrile |
| 5H-Pyrrolo[2,3-b]pyrazine-2,3-dicarbonitrile, 6-amino-7-(1H-benzimidazol-2-yl)-5-[3-(diethylamino)propyl]- |
| TCMDC-123680 |