Topoisomerase II inhibitor 13

Names

[ Name ]:
Topoisomerase II inhibitor 13

[Synonym ]:
6-Amino-7-(1H-benzimidazol-2-yl)-5-[3-(diethylamino)propyl]-5H-pyrrolo[2,3-b]pyrazine-2,3-dicarbonitrile
5H-Pyrrolo[2,3-b]pyrazine-2,3-dicarbonitrile, 6-amino-7-(1H-benzimidazol-2-yl)-5-[3-(diethylamino)propyl]-
TCMDC-123680

Biological Activity

[Description]:

Topoisomerase II inhibitor 13 is a topoisomerase II (Topo II) inhibitor. Topoisomerase II inhibitor 13 shows antiproliferative activity against several cancer cells. Topoisomerase II inhibitor 13 induces cancer cells apoptosis[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase

[Target]

Topoisomerase II

[In Vitro]

Topoisomerase II inhibitor 13 (compound 3m) (20 μM，50 μM) 在 20 μM 时发挥强烈的抑制作用，几乎完全抑制 Topo II 活性[1]。 Topoisomerase II inhibitor 13 抑制癌细胞增殖，IC50 分别为 25.85 μM (MDA-MB-231)、1.82 μM (A549)、10.38 μM (K562)、1.73 μM (Raji)、1.23 μM (HL-60) 和 0.87 μM (HL-60/MX2)[1]。

[References]

[1]. Li P H, et al. Synthesis and mechanism studies of 1, 3-benzoazolyl substituted pyrrolo [2, 3-b] pyrazine derivatives as nonintercalative topoisomerase II catalytic inhibitors. Journal of Medicinal Chemistry, 2016, 59(1): 238-252.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
715.0±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₃N₉

[ Molecular Weight ]:
413.48

[ Flash Point ]:
386.2±35.7 °C

[ Exact Mass ]:
413.207642

[ LogP ]:
3.27

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.721

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.