NH-3

Modify Date: 2024-01-02 19:27:25

NH-3 structure	Common Name	NH-3
	CAS Number	447415-26-1	Molecular Weight	473.52
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₈H₂₇NO₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of NH-3

NH-3 is an orally active, reversible thyroid hormone receptor (THR) antagonist with an IC50 of 55 nM. NH-3, a derivative of the selective thyromi-metic GC-1, inhibits binding of thyroid hormones to their receptor and that inhibits cofactor recruitment[1][2][3].

Name	NH-3

Description	NH-3 is an orally active, reversible thyroid hormone receptor (THR) antagonist with an IC50 of 55 nM. NH-3, a derivative of the selective thyromi-metic GC-1, inhibits binding of thyroid hormones to their receptor and that inhibits cofactor recruitment[1][2][3].
Related Catalog	Signaling Pathways >> Others >> Thyroid Hormone Receptor Research Areas >> Neurological Disease
Target	IC50: 55 nM (THR)[1]
In Vivo	NH3 (46.2-27,700 nmol/kg/day; 7 days) decreases heart rate modestly starting at 46.2 nmol/kg/day, but the effect was lost at >2920 nmol/kg/day. NH3 has no effect on the cholesterol-lowering action of 46.2 nmol/kg/day T3, but it inhibits the tachycardic and TSH suppressant effects up to the 924 nmol/kg/day dose[2].
References	[1]. Latika Singh, et al. Chasing the Elusive Benzofuran Impurity of the THR Antagonist NH-3: Synthesis, Isotope Labeling, and Biological Activity. J Org Chem. 2016 Mar 4;81(5):1870-6. [2]. Gary J Grover, et al. Pharmacological profile of the thyroid hormone receptor antagonist NH3 in rats. J Pharmacol Exp Ther. 2007 Jul;322(1):385-90. [3]. Wayland Lim, et al. A thyroid hormone antagonist that inhibits thyroid hormone action in vivo. J Biol Chem. 2002 Sep 20;277(38):35664-70.

Molecular Formula	C₂₈H₂₇NO₆
Molecular Weight	473.52

DC Chemicals Limited
China
Product Name: NH-3
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

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