SBC-115337

Modify Date: 2024-01-06 11:13:17

SBC-115337 structure	Common Name	SBC-115337
	CAS Number	423148-46-3	Molecular Weight	473.48
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₉H₁₉N₃O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SBC-115337

SBC-115337, as a potent benzofuran compound, is a PCSK9 inhibitor with an IC50 value of 0.5 μM[1][2].

Name	SBC-115337

Description	SBC-115337, as a potent benzofuran compound, is a PCSK9 inhibitor with an IC50 value of 0.5 μM[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease Research Areas >> Cancer
Target	IC50: 0.5 μM (PCSK9)[1]
In Vitro	The potent compound (SBC-115,337) shows an IC50 of 0.6 μM measured in an in vitro ELISA assay to monitor the effect of PCSK9 binding to the recombinant LDLR. SBC-115,337 at 1.2 μM induces more than tenfold upregulation of LDLR in HepG2 cells with respect to the control, increases uptake of fluorescently labeled DiI-LDL and loweres LDL-c levels in mice fed a high-fat diet[2].
References	[1]. Xu S, et al. Small molecules as inhibitors of PCSK9: Current status and future challenges. Eur J Med Chem. 2019;162:212-233. [2]. Lavecchia A, et al. Recent advances in developing PCSK9 inhibitors for lipid-lowering therapy. Future Med Chem. 2019;11(5):423-441.

Molecular Formula	C₂₉H₁₉N₃O₄
Molecular Weight	473.48

DC Chemicals Limited
China
Product Name: SBC-115337
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

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