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423148-46-3

423148-46-3 structure
423148-46-3 structure
  • Name: SBC-115337
  • Chemical Name: SBC-115337
  • CAS Number: 423148-46-3
  • Molecular Formula: C29H19N3O4
  • Molecular Weight: 473.48
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease Ser/Thr Protease
  • Create Date: 2021-10-23 15:19:48
  • Modify Date: 2024-01-06 11:13:17
  • SBC-115337, as a potent benzofuran compound, is a PCSK9 inhibitor with an IC50 value of 0.5 μM[1][2].
Name SBC-115337
Description SBC-115337, as a potent benzofuran compound, is a PCSK9 inhibitor with an IC50 value of 0.5 μM[1][2].
Related Catalog
Target

IC50: 0.5 μM (PCSK9)[1]

In Vitro The potent compound (SBC-115,337) shows an IC50 of 0.6 μM measured in an in vitro ELISA assay to monitor the effect of PCSK9 binding to the recombinant LDLR. SBC-115,337 at 1.2 μM induces more than tenfold upregulation of LDLR in HepG2 cells with respect to the control, increases uptake of fluorescently labeled DiI-LDL and loweres LDL-c levels in mice fed a high-fat diet[2].
References

[1]. Xu S, et al. Small molecules as inhibitors of PCSK9: Current status and future challenges. Eur J Med Chem. 2019;162:212-233.

[2]. Lavecchia A, et al. Recent advances in developing PCSK9 inhibitors for lipid-lowering therapy. Future Med Chem. 2019;11(5):423-441.
Molecular Formula C29H19N3O4
Molecular Weight 473.48

Chemsrc provides CAS#:423148-46-3 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 423148-46-3 | Chemsrc address: https://www.chemsrc.com/en/baike/1682413.html

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