423148-46-3
423148-46-3 structure
- Name: SBC-115337
- Chemical Name: SBC-115337
- CAS Number: 423148-46-3
- Molecular Formula: C29H19N3O4
- Molecular Weight: 473.48
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Ser/Thr Protease
- Create Date: 2021-10-23 15:19:48
- Modify Date: 2025-08-27 11:37:16
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SBC-115337, as a potent benzofuran compound, is a PCSK9 inhibitor with an IC50 value of 0.5 μM[1][2].
| Name | SBC-115337 |
|---|
| Description | SBC-115337, as a potent benzofuran compound, is a PCSK9 inhibitor with an IC50 value of 0.5 μM[1][2]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.5 μM (PCSK9)[1] |
| In Vitro | The potent compound (SBC-115,337) shows an IC50 of 0.6 μM measured in an in vitro ELISA assay to monitor the effect of PCSK9 binding to the recombinant LDLR. SBC-115,337 at 1.2 μM induces more than tenfold upregulation of LDLR in HepG2 cells with respect to the control, increases uptake of fluorescently labeled DiI-LDL and loweres LDL-c levels in mice fed a high-fat diet[2]. |
| References |
| Molecular Formula | C29H19N3O4 |
|---|---|
| Molecular Weight | 473.48 |